Canagliflozin for healthy people over 50?
With the ITP paper on canagliflozin, and other evidence of cardiovascular risk reduction and renal function improvement, plus longterm safety, what are your thoughts on appropriate dosage/protocol for use of canagliflozin for potential healthspan/longevity benefits?
Fasting and cortisol
When I fast (just 24-36 hours) I feel fine during the day, but I wake up at 4 am feeling very stressed. My fasting blood glucose tends to be relatively high before 9-10 am on these days. I suspect an increase in cortisol due to the fasting is driving the early waking and higher fbg. Does it still make sense to fast in this case? (I’m a female in my 50s if it matters.)
Can doing long runs 1.5 to 2 hours while fasting bring about better fat metabolism?
So it appears aerobic improvement improves inclemently for each minute up to around 45 minutes, then the improvement slope flattens slightly and then gets steeper as you get closer to 2 hours. If one were to do train in a fasting state would the 2 hour improvement slope arrive earlier...say at 1.5 hours?
CGM Choices
I'm not prediabetic but considering getting a CGM. Additionally, I hope to participate in the Alzheimer's prevention study looking at blood glucose levels with the aim of early detection and to better understand the relationship between Alzheimer's and Blood Glucose. I think I've listened to everything I can find on your site about CGM's and you clearly favor Dexcom, but don't delve into the details beyond "accuracy". Given the difference in price $428/mo for Dexcom and $198 for Abbott, I'd really like to know how much accuracy I'm giving up (and any other features) for that 55% increase in price. Thank you!