Exercise speed and progressive overload
isn’t the concept of progressive overload somewhat negated by the fact that you get faster at doing the exercise? For example, if you can do five reps in 20 seconds and then six months from now you can do 15 reps in 20 seconds is this one way to approach it where you don’t have to think about adjusting and increasing your weight until you’re literally doing it at a pace that is unreasonable? If that is true, should you use a specific time such as 30 seconds or one minute and then once you do a certain number within that timeframe increase your weight and use time based progressive overload or do you suggest weight based progressive overload? Thanks.
Osteoarthritis and exercise advise for seniors
I find that most of your podcasts are aimed at middle aged people. Since I am among many (and I know of quite a few) retired seniors who listen to your podcasts I encourage you to address more of your advice to that demographic. I am a73 year old woman who started weight training at age 27 and have continued throughout my life. I have incredible bone density, but compromised joints. I have severe arthritis, have undergone joint replacements, and I'm waiting for more. The cervical spine causes me the most grief. I do however continue to do resistance and zone two training. I have transitioned from lifting weights to Lagree Fitness which incorporates resistance training, core strengthening, and stretching without the pressure on joints. The exercises are done on a megaformer. I would love to hear best strategies for seniors who are committed to eating healthy and exercising as best they can given the challenges of aging. Challenges that have also included a stroke in the cerebellum for me, that I am told is mitigated somewhat by my exercise that has restored balance losses, and my higher education that's helps me hide my struggles with memory. I hope you will find some experts to interview who will address these issues. Many thanks. Love the work you are doing!!!!
Request for a guide to med school episode
Hi there, I am a first year med student and your podcast and the experts featured are keeping my dream alive admit the often demoralizing memory game of med school. I am sure I am not alone and would love to hear an episode on your experience through medical school and any tips you might have. It would be great to hear from some of your colleagues as well (I’d be particularly interested in hearing from Paul Conti given he entered with the intention of being a psychiatrist)
GLP-1 for Bariatric Patients (Roux-en-Y)
I had gastric bypass surgery 13 years ago (went from 280 lbs to 145 lbs over 1 year but continue to find myself 'yo-yo' dieting. I'm 80 years old and exercise vigorously (hiking/walking 3x/week for total of 12 miles plus 175 ft of elevation gain each time and biking 3x /week for 48 mile per week). I'm drawn to certain foods (carb loaded and sometime sugary) to calm me down when stressed. Is GLP-1 a solution for me? My a1c reading is 5.9. I've always been per-diabetic my entire life even as a kid. Currently my weight fluctuates between 158 and 180 lbs.
Sex after SBRT radiation for prostate cancer
I had SBRT treatment in 2020. Almost immediately my orgasms became dry. Several minutes after orgasm there is some leakage. I assume it’s semen. Is there sperm in that? 2 years later my erections became weak. Viagra no longer helped. My urologist prescribed trimix. That helped but was unpleasant. I’ve since lost weight and can mostly function without trimix. Can I get a woman pregnant? Is there a way to improve semen flow or did the radiation destroy it? I now take daily cialis. That helps with erection strength and urinary flow. But urination is still weak. Any other recommendations?
Creatine supplementation and eGFR
I am a female turning 50 on 12/8/25. I weigh 125 pounds and am lean versus muscular, but generally fit. I try to supplement with 5g of creatine on days that I exercise which is most days but I am not always consistent with supplementation. That being said, I was taking it more consistently in January and November of 2025 and my lab work (below) reflects that. My endocrinologist (seeing for low bone density at age 50) told me after my last set labs (taken before I did a Reclast infusion) to stop taking creatine and retest to see if my creatinine lowers and my eGFR goes back up and then if stopping normalizes my lab results she said that it was my decision to keep using creatine as a supplement. I understand this is not her wheelhouse but I was wondering how long I would need to stop taking creatine for a retest (she did not tell me) and if there is a true concern about a higher creatinine and lower eGFR. I asked my MD about doing a cystatin-c test after listening to one of your podcasts and she said there was no reason to do that test and to stick with the typical eGFR. I may just pay for that if I can get one without an order. I would like to keep on using creatine for muscle and ultimately bone health seeing I already have low bone density for my age, but maybe these results show that I am not good a candidate for the supplement. Curious what your direction would be. Thank you and for all your amazing work! 1/30/25 eGFR 82 creatinine .87 - Labcorp 3/27/25 eGFR 99 creatinine .74 - Labcorp 9/13/25 eGFR 96 creatinine .76 - Labcorp 11/13/25 eGFR 73.4?creatinine .95 - hospital lab
Upheaval in the evidence based lifting
We all just witnessed the downfall of Mike Israetel’s reputation, after his phd thesis was publicly demolished. I personally felt betrayed by many people I used to follow, because the shockwave from the fall of the giant spread far and wide, hitting many other influencers including Layne Norton and Jeff Nippard. In the last weeks I found myself getting down the rabbithole of Lyle McDonald’s content: he sounds harsh and unpolished, very old school, but in a way felt like fresh air. Would you consider having him on the podcast? I think your no bs approach to science would go nicely with someone like him.
Stem cell iv
A 65 y.o. Friend with significant foot neuropathy and back arthritis went to a clinic in Los Gatos CA to an MD with an impressive educational background who removes stem cells from abdominal fat and rejects them via an IV by a specialty method she developed for the cost of 15k. He has had significant improvement and is in contact with several other patients with similar good results. I’m struggling with the lack of research. Dr reports she is being squashed by big pharmaceutical but she changes lives daily. Do you have any thoughts about this systemic delivery of stem cells?
Osteoarthritis
First of all, absolutely love what Peter and the team does there. You truly are AMAZING!!! I've been a long time listener and learner. I would truly appreciate if you could please do a dedicated episode on Osteoarthritis. Perhaps you could include such subtopics as understanding the basics, causes & risk factors, symptoms & diagnosis, treatment options, prevention, pain management, the latest/emerging research, future outlook, etc? I have searched the website and have not found a focused episode on this topic, but would love to hear a deep dive into it as it has significant impact on my family. Thank you.
PCSK9 inhibitor non responder without familial hypercholesterolemia
Please go into this more. I'm intolerant of both statins and ezetimibe and appear to be a non responder of PCSK9 inhibitors (2 months into Repatha). My cardiologists tells me with my E3/E4 genetics, I'm a hyperproducer of LDL however my LDL was below 100 until menopause. I've been on HRT for 5 years. I feel like a case study... Calcium score is zero.
Fructose common pathway for Alcohol Use Disorder, liver damage, and MASLD
The article from Nov 10, 2025, in Nature Metabolism, by the team at University of Colorado Anschutz, and the press publicity about it, seem to indicate that the way to intervene with liver damage from bad diet and treat AUD is by disrupting fructose metabolism - this seems to echo work from Dr. Lustig years ago. Is there more than the mouse models in the recent study to indicate this same pathway is active in humans as a main or predominant target for intervention?