Should HRT initiation limited to 10 years post menopause be revisited.
Based on the Lancet article "Is it time to revisit the recommendations for initiation of menopausal hormone therapy" by Sasha Taylor and Susan Davis, should women with osteoporosis reconsider the use of HRT even if they are older than 60 and 20 years past menopause?
Creitine effect on HPT and urinary issues
Can taking creating lessen Medium HPT suptoms ? Have studies been done that showed any conclusions ? When I took my first dose of creating my urgency to constantly have to urinate almost completely disappeared. The best dat I’ve had in several years. My physician doesn’t really know much about the world of exercise or the supplements. He encouraged me to proceed with the TURP in mid July. Thinking of rescheduling, but I probably can’t afford take creating my whole life{I’m 75} but I will have to pee the rest of my life. On the fence about the surgery, but I’m really gonna do it. Thanks in advance for your response.
Carotid sonogram or MRA carotids in asymptomatic person
I'm an 80 yo retired radiologist with 3 vessel coronary artery disease and CTA or coronaries over 2000 with no coronary symptoms. Coronary angio showed no lesions of 50% or greater. I have well controlled hypertension and well controlled hypercholesterolemia with rosuvastatin, ezetimibe, and repatha. As a side note, I have always exercised alot and still walk 1.5 miles a day, ride the bike 10 miles a day and do some of the p90x workouts weekly but usually only the first 30 mins. I only became a real advocate for my own health with my internist after beginning to listen to your podcasts, not previously realizing it was not okay to be within normal limits. After hearing your podcast about half the people who die of atherosclerotic coronary artery disease have death as their first recognized symptom. I then asked my internist to order a CTA or the coronaries for which he referred me to a cardiologist. After the CTA was non-diagnostic due to the high calcification I requested a coronary arteriogram. Though my cholesterol and triglycerides were wnl range I pushed to add ezetimibe and repatha. Thanks to you for all your discussions in your shows.
Diet / Exercise Protocol for Preventing Recurrence of Glioblastoma
Hey Peter! My dad had another clean scan this week after surgery and treatment for glioblastoma. I know there's no cure but what diet / exercise protocol would you recommend for someone looking to delay recurrence as long as possible. He was on rapamyacin before treatment and isn't sure if he should go back on. Thanks in advance!
ANA Pattern - Function Health Biomarkers
I recently got my results back from my blood test with Function Health and my ANA Pattern was out of range (mitotic, intercellular bridge). I reviewed AMA #59 on inflammation and you did not mention this test/biomarker as something you typically review. Has that changed since that episode was released? Is this a test that you occasionally run? Would love your thoughts on why you do or don’t run it and if it’s something that can be beneficial.
Recent developments in blood screening.
My daughter, a PCP in Los Angeles , recommended that my wife and I take a cancer screening test by Callari. She works in a concierge practice and employ the test with all of their patients. My PCP in Pa is hesitant to prescribe it because of his concern for false positives. This test among others was featured in a recent WSJ article on their rapid growth . I think a deep dive with experts would be a great subject for an Ask Me Anything poscast. Thanks.
Have I missed coverage of Alzheimer’s risk factors
As someone who’s followed your work for 15 years, I appreciate your precision in distinguishing correlation from causation. In the Alzheimer’s risk landscape, APOE4 is clearly dominant but immutable—while fasting insulin shows up as both highly significant and modifiable. Yet it seems relatively underrepresented in cognitive health discussions, including yours. Is this due to gaps in the research base, unresolved causality, limitations in clinical translation—or gaps in my uptake of your coverage?
Sets & Reps for Exercising 1 Body Part/week
Hi: In AMA #71, Peter talked about his personal workout routine of 1 body part/week. I'd like to know if you can give a good reference for doing it or can give me the general range of sets & reps per body part to use. Also, Peter talked about working apposing muscle groups, i.e. bis/tris or chest/back. Again, can you give a reference to get better educated on it, Thanks,
Fasting glucose levels
I have heard Peter say on occasion his morning glucose levels tend to be high. With a family history of diabetes I watch my carbohydrate intake carefully and even with the addition of Jardience and metformin and an A1C of around 5.6, my morning numbers remain slightly "hot" and out of recommended range ( 5.6 or 5.7 in Canadian terms). I sleep decently. Is there some explanation or metabolic phenomena that explains what Peter or I experience?
biomechanics and longevity
Hello Peter, my name is Miroslav and my english is poor so I hope the chatbot made a good job. Here is my question- topic for discussion: Movement is the third most important thing for life, after air and water, and the first one we can consciously and purposefully influence. People who have lived over 100 years probably had naturally good biomechanics, which allowed them to move into old age, and perhaps it is precisely because of this that they reached this age. Movement positively influences the cardiovascular system; during exertion, the body cleanses itself – through breathing and sweating – and it has a positive effect on digestion and mental health as well. It would be interesting to look at those over 100 years old from the perspective of their biomechanics: height, alignment, and geometry of joints and the spine…" You and your team are doing a great job, congratulation. It's for me a great pleasure to support you. best
Do these "hangover" pills really work? Is the science behind them valid?
I've seen lots of ads for hangover pills, e.g. https://products.bestreviews.com/best-hangover-pill? I've bought some "Cheers" pills and for at least 1 day post a few drinks, it seemed to make me feel better, but since then results have not been consistent. Are these things legit?
TRT and mitigating the catabolic process in elderly men
TRT and alleviating the 'sexual symptoms' in elderly men who are in (late onset) male hypogonadism(tested) is a hot topic. But what about the relationship with body composition en the overall more catabolic state in elderly men? CASE: I am a emergency physician ,52 y old , I do resistance training frequently , I eat healthy nutrient rich foods , I work regularly on stress relief with meditation and yoga nidra, I try to sleep enough ( but ofcourse I have nightshifts..) I do have symptoms on the sexual level but what I see also is that I lose weight (maybe because I do a lot of exercise and eat a lot of protein?) and have exercise intolerance ( fatigue afterwords+) and I feel a more catabolic state in my body... my recent labs are great but show I am in a state of (mild) hypogonadism, free T < 100 picogram / ml (84.6), I talked with Dr Morgentaler Abraham , there is a indication for TRT. I just wandered , if I start TRT is there literature on the bodycomposition part / catabolic symptoms ( which I perceive as catabolic, being losing weight , excercise intolerance )? So what is literature showing on the plan on alleviating catabolic symptoms outer of the 'sexual' symptoms, because honestly I am more concerned about being in more catabolic state then the sexual symptoms ( which of course do bother me too). Because I would be more convinced to do the TRT when science tells me there is a proven benefit on that topic also. Of course it is an anabolic product but is there a proven scientific evidence to start TRT for that reason, again apart of the sexual symptoms also. Thank you Peter for all you do in the world and science , it has great impact... it really does.. You talk about medicine 2.0 and 3.0... fantastic, so inspiring, thanks !! kind regards
Metabolic Psychiatry
What are your thoughts on Dr. Ede’s book, Change Your Diet, Change Your Mind? She recommends a keto diet to help with depression and other mental health issues. Do you think a keto diet is unhealthy? She states that fiber isn’t necessary in our diet. What are your thoughts on that?
Carbohydrate timing
As a 60 yr old woman looking to increase muscle mass, I have read that consuming sugar or simple carbs (30-50gm) with protein after working out would be optimal, particularly if you are working out in a fasted state. The podcasts I've listened to on protein haven't approached this topic. Also, many protein supplements contain 0 to little carbs leading me to believe that this idea may not be true or have little effect. So, my question is, which is the best way to increase muscle mass...protein with high carbs or protein with no/low carbs?
Dealing with intra- and interindividual variability
Hello, big fan of the podcast - it's a key source of CPD for me, and I really appreciate both your approach and also the clarity of presentation. Thank you for all you do. I'm a physician with an interest in environmental physiology. The key challenge in our evidence base is bridging the gap between lab work (high control, low ecological validity) and the complex outdoor environments we care about (low control, high validity). Sample sizes are often small, and RCTs are rare. I've really noticed that variability within individuals, as much as between individuals, can be a key a confounder. When you appraise studies of human performance and try to integrate them into your practice, how do you account for individual participants 'having a bad day'? I've read about some techniques, including time-series analysis, but I confess they quickly exceeded my meagre brain. I would love to better understand your approach. As an aside, I'd also love to hear you interview Prof Mike Tipton, chair of the Physiological Society - he's had an incredible career in basic and applied physiology, especially wrt to environmental stressors, sea survival and prevention of drowning. https://www.port.ac.uk/about-us/structure-and-governance/our-people/our-staff/mike-tipton Thanks and best wishes!
processed meat / maui nui
I know you're a fan of maui nui venison sticks, I am as well. Do you believe these fall under the category of processed meat, which seems to be universally considered a serious carcinogen. There are of course some additives. Overall, trying to determine if these are a good supplemental source of protein (and a healthy daily snack) or a once-in-a-while snack. Thank you!
AFIB
AFIB is highly prevalent, especially among individuals aged 60 and above, significantly impacting overall healthspan. Given its widespread implications across various dimensions of health, it's surprising that this topic hasn't yet been addressed thoroughly in podcast form. Perhaps it's time to explore atrial fibrillation more deeply and comprehensively in an upcoming podcasts.