Lumbar disc disease
As a surgeon myself, I have typically recommended against spine surgery whenever possible. Unfortunately like you, I suffered an issue that required immediate intervention (far lateral disc herniation on the DRG). Thank you for sharing your own saga with your spine and it is remarkable how you have addressed it. Back pain is currently the biggest cause of disability as well as loss of quality of life, and an estimated $200 billion are spent annually on it worldwide. Would you and your team consider discussing back pain, spine rehab, surgery, PRP, stem-cell therapy, and any novel regenerative medicine interventions as they relate to low back pain? Considering the prevalence of the problem and its effect on quality of life / the centenarian decathalon, I think your subscribers would gain tremendous value in sharing your thoughts and those of other experts in the field.
Root process leading to overabundance of Diacylglycerol
Gerald Shulman in his (excellent) master class on insulin resistance described the role of fat inside cells in driving insulin resistance. Could you please take a step back and explain why the diacylglycerol (DAG) is in the cell in the first place? Are people getting this problem because of eating too much fat? Or is it because of mitochondrial inefficiencies that don’t allow the muscle to properly burn a normal fat diet? Or does it have some other dietary or genetic cause? Do all people have some DAG in their muscle cells? Or is this a particular defect associated with a pathological condition? Since the presence of DAG seems to cause insulin resistance and be caused by insulin resistance, it is a vicious circle. But what causes the initial problem? What starts the cascade of too much DAG? Thanks so much for your answer.
Prednisone....:(
Hi Peter, I just wanted to pop in and say I'm so sorry about all this stuff you're going through with your larynx. I had to go on 40 mg of prednisone for 5 days in January to knock out a stubborn upper respiratory infection and I was nearly suicidal (not really) because I'm wearing a Dexcom 6 and my blood glucose readings looked like I was on a non-stop 5 day ice cream binge! All I could do was sit there and watch it climb, it was really torture. I would have just taken the Dexcom off but I was in the middle of a 10 day cycle and was too cheap ;). Anyway... why is prednisone a go to drug in these situations and why does it do that to blood glucose? It feels like a real sledge hammer of a drug. Hope you feel better soon!