Effect of Autophagy on Vascular Calcification
Hi Peter, I came accross this very interesting study about the effect of Autophagy on Vascular Calcification. I would live to have your view on this: https://www.mdpi.com/1422-0067/21/23/8933/htm?fbclid=IwAR3mSW9LyVybdFwRXboH4rr136iQZiP-84fWA8wpPuuMTYZZ9KPVByhrJm4
Metformin and Statin use (ad-hoc)
Hi Peter, I’m a 38yo woman super interested in longevity after having early stage breast cancer 3 years ago. I wear a CGM and have been fascinated with your insights as well as your topical AMAs and thoughts around blood glucose control. I’ve recently shifted my diet to a low carb, moderate protein and fat (fish and some low fat cheese like feta but mostly plant based fat) and have noticed my lipids going up. I’ve got a BMI of about 19, exercise regularly (5-6x combo HITT and zone 2 plus strength), sleep is decent but have always had lipid profiles higher than optimal. I’m concerned my switch from WFPB to include more fats will further increase my lipids. I’m going to do bloods (and include apob this time!) in 3 months time to check but in the interim I would love to hear your views on using metformin intermittently (500mg) if I’m planning to eat a higher carb well as a preventative (so say once a week, on the weekend) aside from behaviour reasons you might not (might encourage me to eat more carbs) do you think this is beneficial? Likewise with taking a statin maybe twice a week, 40mg? Really would love to hear what you think!
Training for parents with young kids
I have two kids under the age of three, and some weeks me and my wife have to make some tough priorities with regards to what training we are able to complete. This is usually due to sleep deprivation, and happens on average one week per month. Our ideal strength training weeks consist of four sessions split into two upper body and two lower body sessions. Some weeks we are only able to complete two sessions. If you were in that situation, would you do two full body sessions or one upper body and one lower body session? I have a similar question with regards to endurance training. An ideal week consists of three zone 2 and one zone 5 session. Some weeks we can only complete two of those sessions. If you were in that situation, would you do two zone 2 sessions, one zone 2 and one zone 5, or two zone 2 sessions with zone 5 at the end of one of them? Our goals with the strength training is to increase muscle and bone mass, and with the endurance training to increase mitochondrial health and VO2max. I would love to get your take on these questions. Keep doing what you're doing, it is tremendously helpful.
Definition and the practice of a "rest day"
Please help define the practice of a "rest day" with in the context of your recommendations. Is it necessary? What does it look like? If one were to walk for 45 minutes every day. Do zone 2 LT on a bike 4-5 hours a week. Accumulate 20-30 minutes of zone exercise, and practice strength training 2x week what would a rest day look like if necessary?
Increasing longevity and biological milestones
All discussion I've heard regarding longevity is centered on improving / maintaining physical and mental health to prolong a healthy and fulfilling quality of life. But is there any work being done to increase lifespan that would include corresponding delays of biological milestones, most notably menopause (but could also include puberty, etc.)? I visualize it being like a lifetime rubber band that is stretched 20% for example, and these milestones would move out accordingly.