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Melatonin safety

In podcast 202 you mention: "Peter says that Phenibut is an amazing sleep supplement where you could use it frequently without any concern, unlike Melatonin, for example, where you really have to be limited in how much Melatonin you’re using and how often." Can you elaborate on the concerns around Melatonin and the max dosage for nightly use?

Brain aneurysm

Is there a criteria for detecting brain aneurysm’s without symptoms? Say starting at 35, 40 and so on, maybe using a cerebral ct scan with contrast to view blood vessels? Would this cause more risk than benefit? What can you do to prevent a brain aneurysm? Deadlifting and other intense exercises seem to increase pressure in the head which one would think this could cause an aneurysm. What are your thoughts on any data out there? Is there a treatment for an unruptured aneurysm that does not involve brain surgery?

Deep dive on autoimmunity

Hi there doc! We get a lot of content on ASCVD, neurodegenerative diseases and cancer, and your podcast provides quality like no other on the interwebs. But I'm still at a loss (and I feel many other here are as well) on everything autoimmune disease related. I hope there will be some discussion on the drive to shed light on this extremely impactful topic! Thanks

Are all the health benefits from TRF really just Calorie restriction?

Are all the health benefits from TRF just Calorie restriction? Would a person snacking on the same number of calories hourly have the same health as someone with a feeding window? Do manipulations in thyroxine and ketone production or undertaking activities in a fasted state provide no real health benefit? Thanks

Drug prevention treatment for breast cancer among individuals with pre-cancerous cells

Hello - what are your thoughts on chemotherapy prevention for breast cancer among individuals with pre-cancerous cells in their breasts? For example, Anastrozole?