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3

What are the dangers or negative side effects of extended HIIT sessions?

I'm a 38 year old man and have been doing ~2 sessions of ~3 hour BMX style cycling (street trials). I recently started using a Polar HR monitor. Results are typically 30-50 min zone 5, 90ish min zone 4, with the rest mostly in zone 3. I feel healthy and have not had issues with recovery. Could there be damaging side effects I am missing?

3

Is there any evidence that "organic" foods have a health benefit?

Is there any evidence that "organic" foods have a health benefit? Especially as related to cancer, or other diseases. Probably not much research on longevity benefits? What's your take on organics?

3

Myocarditis and mRNA vaccine safety

https://www.cdc.gov/mmwr/volumes/71/wr/mm7114e1.htm Does this represent a definitive resolution on this question? You’ve made statements previously that seem to contradict this data. Your team is so good at clarifying complex data I’d love to hear a brief analysis. Thank you for all the amazing work.

2

Metformin substitutes and birth defects

In light of the recent Stanford University study suggesting that Metformin might cause birth defects in male children, I'm wondering if there is a similar concern with other glucose lowering drugs as well such as Acarbose and Canagliflozin.

7

Lipids vs glucose, which is more important?

Which is more important, good control of glucose and Lp(a) with a low carb diet or good control of LDL-C with a low fat diet? Sarah Hallberg has demonstrated that a low carb diet controls and even reverses type 2 diabetes. David Ludwig published in January 2022, in the American Journal of Clinical Nutrition, that a low carb diet lowered Lp(a) whereas a high carb (low fat) diet raised Lp(a). A recent Webinar sponsored by the Family Heart Foundation, with Calvin Yeang as presenter showed how a low fat diet and statins raise Lp(a). Shouldn't we be doing low carb instead of low fat?