Free T Calculator/Reliable Sources
I have conflicting MD opinions on my Testosterone. It seems Free T (the important piece) is just a calculation (Albumin, SHBG, Total T), correct? Is there a reliable online site for that calculation if you have your numbers AND a chart that tells you whether that number is low? Scheduling an endocrinologist is over a year. How can there be disagreement by MDs on a calculated number? It's a big deal to me - to HRT or not. Thanks!
Free T Calc / Reliable Sources
I have conflicting MD opinions on my Testosterone. It seems Free T is just a calculation (Albumin, SHBG, Total T), correct? Is there a reliable online site for that calculation if you have your numbers AND a chart that tells you whether that number is low? How can there be confusion on a calculation or straight numbers? Seeing an endocrinologist is a year away and it's a big deal to me - to HRT or not. Thanks!
PCSK9 inhibition---Concerns about adverse effects on cognition?
Are you concerned about studies showing Negative effects on cognition for PCSK9 inhibitors (some studies showing they are even worse than statins) e.g. see https://pubmed.ncbi.nlm.nih.gov/26578202/ (2015) see https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944510/ (2020) After listening to all of your podcasts on cholesterol lowering medications, it seems like PCSK9 inhibitors should be the gold standard. But I don't think I've heard you discuss risks... (e.g. PCSK9 inhibitors reduced the incidence of all-cause mortality [OR 0.43 (95% CI 0.22-0.82), P = 0.01] but was associated with an increased incidence of neurocognitive adverse events [OR 2.34 (95% CI 1.11-4.93), I(2) = 4%, P = 0.02] when compared with placebo.)