DNA Methylation
Throughout various podcast episodes it seems you are not convinced that DNA methylation is a valid metric for measuring aging. Given that consumer-direct biological age tests are becoming more prevalent, it would be helpful if you had an expect in this space on your podcast to discuss the nuances of attempting to measure true biological age using DNA methylation. I really appreciate the knowledge you’ve shared with your listeners. Thank you.
Electrolytes before, rather than during a workout.
Peter, Near the end of AMA #33 while talking about diluting your electrolyte solution, you mentioned "there's nothing I actually like more than water when I'm exercising." I feel exactly the same way. So I actually drink an entire serving of Nuun about 5 or 10 minutes before I work out. (1 tablet, in a little less water than they recommend -- 10oz instead of 16oz -- just because it's a lot to drink at once.) And then I drink plain water during/after exercising. In general, do you see anything wrong with this approach? I suppose it wouldn't make sense for exercise that goes on for several hours -- you'd really want to spread it out over the duration. But for a workout of an hour or so, what do you think? Assuming it's some type of exercise where you'd actually benefit from taking electrolytes. And assuming you don't mind the taste and guzzling that much water before a workout.
Beta-Alanine
Beta-Alanine has been one of the most effective exercise supplements I’ve taken. I’ve read this is due to increasing muscle carnosine, and that this may delay blood lactate accumulation. How would supplementation effect the Zone 2 mitochondrial exercise discussed by you and Indigo? Would it possibly allow greater watt/kg while maintaining fat oxidation? Most of its performance benefits have been measured in high intensity exercise, but I haven’t seen anything analyzing the zone 2 threshold issue.