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4

Consumption of MCT products while consuming carbs?

I'm wondering whether products containing MCTs should be avoided while on a diet that consists of moderate carb intake (thinking: carbs (glucose+insulin) + MCTs (ketones) = harmful when both present in your body)? If so, should avoidance be absolute, or is it dose dependent? For example, while consuming carbs, would 1-2 grams of mixed MCTs in a coffee creamer be equally bad as adding 15g of C8 into a drink? Thanks!

2

Effect of rapamycin on renal function

In your discussions with Matt Kaeberlein, or in general, do you know how rapamycin affects the kidneys in healthy humans, dogs, or mice? Do you know how rapamycin affects the kidneys in humans, dogs, or mice with elevated renal biomarkers?

1

Ray Peat / Bio-energetics

Can Peter give his take on Ray Peat's "bioenergetic" perspective on health and metabolism? Peat is notoriously pro-sugar for it's pro-metabolic/anti-stress mechanism, and it seems to work well for many of his followers.

6

"Biohacking" debunking/support

Can Peter give a nuanced look at some of the major Ben Greenfield-type biohacking modalities - photobiomodulation, PEMF, grounding, methylene blue, EMF-avoidance, etc.

1

1,5-Anhydroglucitol

Murray Rosenthal here. As I mentioned previously, I helped invent the first commercial HbA1c test. For the last 30+ years, I have been mildly interested in the 1,5-Anhydroglucitol (1,5-AG) lab test (tradename Glycomark). For individuals who maintain their dietary habits, I believe that the 1,5-AG test gives you an indication of area-under-the-curve for glucose levels. Your last AMA podcast talked about CGMs and I think that is the best way to measure glucose excursions. However, for those people that can't afford a CGM, what about tracking 1,5-AG levels over time? Thus, HbA1c tracking gives you an idea of average blood glucose and 1,5-AG gives you an idea of average glucose excursions post-prandially. What do you think?