When the Numbers Don't Seem to Compute (or maybe they do)
Is there a "ceiling" for favorable HDL? I understand that an NMR profile would reveal more, but I recently had a conventional profile workup through LabCorp (I've had many of these done over the years) and my HDL was very high at 147 mg/dL (usually around 100), and my TGs very low at 41 mg/dL (lately in the 60s-80s). Further, my AST was higher than ever recorded at 63, and ALT at 44. A few background facts: I'm a 53 year old male, an endurance runner (and have been for ten years), and have regularly been running 30+ miles per week (most runs 13 miles). I do brief body weight workouts every morning. I am a small guy at 5'8" and 130 lbs. I consume a lot of protein (200 g/day), lower carbs (40-50g/day), and moderate fat (120-160g/day). I am taking 1-3 capsules of Carlson Maximum Omegas per day to mitigate normally high TG levels. I am a "moderate" drinker, consuming 1-2 drinks every evening. Is it reasonable to assume that with all these mixed input variables that it could be difficult to tease out at least a clearer picture without imaging of organs like the liver, kidneys, and pancreas (and so on)? I understand that you cannot in such a context offer medical diagnosis or advice, but I respect you and your team's opinion greatly and frankly don't trust my local offerings. I don't have a GP at the moment as I'd given up years ago finding one in my area who doesn't advocate a SAD diet and who cannot afford more than a 12 minute timeframe to meet my health needs. Having said all that, I appreciate greatly your time and any general insights you might over. Best regards to you and your team.
Restoring the microbiome after antibiotics
I listened to Episode #91 with Eric Topol. Ability to manipulate the gut microbiome and it's implications was discussed during that episode. I work in a hospital, where the use of IV antibiotics are commonplace. I am wondering if there are any evidence-based protocols for restoring the gut microbiome that could be prescribed following a course of, presumably needed, antibiotics? Thanks!
Urolithin A induced mitophagy for anti-aging
What are your thoughts on Urolithin A, the metabolite found from ellagitannins such as pomegranates? It's been shown to induce mitophagy, extending rodents' lifespan by 40%. It also turns on anti-aging gene expression and improves leg strength in adults.