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1

PCSK-9 modified with CRISPR

Hello Peter et al. An AMA or interview that includes the ongoing trials by Verve Therapeutics’ to modify PCSK-9 expression with CRISPR would be interesting. Thanks!

7

Is it possible to reverse calcium deposits in coronary arteries?

If a CAT scan has shown calcium deposits in a coronary artery (70 year old male) is there a way to reverse the process and decrease calcification through diet, exercise, or drugs?

10

How can I become a patient?

How can I become a patient?

1

Heart Rate Variability for Longetivity

Hi Peter, I'd like to know what your thoughts on HRV are (Heart Rate Variability) and whether it is better for longevity to do exercises in waves/intervals (HIIT) that icrease HRV? I've heard other experts say this is the best way for longevity to mimic the sympathetic and parasympathetic nervous systems.

3

Endurance Exercise and Your Heart

Hi Peter, I'd like to know your thoughts on how Endurance exercise instead of HIIT can effect your heart. Specifically the book the "Haywire Heart" by Chris Case talks about doing endurance exercise for more than 1 hour a week for 5 days a week creates functional changes in the heart which can lead to Cardiomegalgy/hypertrophy, or extra beats, arritymias, and Bradycardia. It is been suggested that HIIT may be better for the heart.