Is lactic acid or lactate produced in the body?
I was reading some studies and papers regarding lactate and lactic acid and came across this: https://journals.physiology.org/doi/full/10.1152/physiol.00033.2017 They claim that lactic acid cannot be produced in the body. I do not have quite enough understanding of the organic chemistry and acid-base stuff to know whether this is true or what the implications would be. Do you have any insights on this paper and their assertion that it is physically impossible to produce lactic acid in the body? Thank you.
Gallstone risk from TRF and IF?
I've heard that various types of TRF (e.g. 16:8) or IF can increase the risk of gallstone formation. (1) Is this true, and if so, what are the data supporting this? (2) If true, does this only apply to those that are losing a lot of weight? (3) What if you are not overweight and just trying to extend your overnight fast a bit longer for longevity benefits, do you still have that risk? Thanks.
Lactate shuttle & Metformin/Berberine
Feel like this has been at least addressed in some form before, I'll search through the notes as well. I'm starting a business implementing metabolic testing via RMR & cycling/treadmill Ramp Testing. It would be good to know this mechanism by which medication could inhibit this usage of lactate? If I'm wording that correctly... As well as what that would look like in the metrics. (Full cardiac/resp/pulm available)
Dry Fasting
Around 1 billion people "dry" fast from sunrise to sunset for a month annually as part of an Islamic Ritual during the month of "Ramadan." What is your take on fasting for 16-18 hrs per day for 30 days without food and water? Does fasting from food and water increase or decrease the health benefits of fasting?