Is autophagy or mitophagy local of systemic? Does physical exercise as running or cycling produces systemic autophagy or just local?
Many podcasts and AMAs discuss biological and physiological mechanisms in detail and explain them wonderfully. The mechanisms such as autophagy, mitophagy and glucolysis and lipolys are often discussed in muscles or the liver. I often wonder whether the effects are local or systemic. For example, if I go running/cycling and induce auto/mitophagy in my muscles, is this a local effect or does this also cause an energy deficit in the neurons in my body or in my brain? Could anyone answer my question about this or recommend some articles to investigate this.
Therapeutic use of MDMA and classic psychedelics
I'd love to hear Peter's opinion and/or experiences with MDMA or classic psychedelics. Does Paul (Conti) have opinions and medical experience with these substances? An episode exploring these topics would be very helpful and interesting. I'm studying this as in Australia as the law changed in July for MDMA & psilocybin to be prescribed by psychiatrists (for PTSD and TRD, respectively). Love the podcast, and grateful to the backend crew for all their input & support 😊
Mild burden of chronic deep white matter ischaemia
Hello Peter, I am a 56 year old male and I recently had a head and body MRI as part of a full health check. I was diagnosed with a mild burden of chronic deep white matter ischaemia. There was no mass or evidence of acute infarction. My question is what is the best treatments to manage this disease from an exercise, supplements, pharmaceutical and lifestyle point of view? I am on statins and nexium. Australian stats. Apo A1 1.90, Apo B 0.77 Lp (a) 6, Glucose random 5.3, Insulin 3.4. Exercise 6 days a week, Zone 2, VO2 Max and weights. Thank you.
High HDL increased risk for Dementia
I thought high HDL was good but a new study noted that high and low levels of so-called "good" HDL cholesterol could increase the risk of dementia in older adults. My HDL is 81, which I thought was good but based on this study https://n.neurology.org/content/early/2023/10/04/WNL.0000000000207876 I am at increased risk of Dementia. Thoughts on this study and ways I can lower my HDL specifically.