NSAD’s for chronic inflammation
I am a very active 64 yo female. Hike, ski, bike, weight train and other misc activities. About 5 years ago I had a total knee replacement and it has been no less than a miracle allowing me to return to all that I love. However I have chronic inflammation in the TKR knee and have been on NSAID Meloxicam. What do you think of long term use? I am fearful of having chronic inflammation and what it does to my health. My C- reactive protien is above normal without the nsaid
What are the implications for Low Dose Colchicine (LoDoCo) for ASCVD risk reduction and inflammatory drivers of the Hallmarks of Aging?
Last month “Lodoco”, a branded low-dose colchicine (0.5mg rather than 0.6mg but otherwise identical), was approved by the FDA for the treatment of those with high risk atherosclerotic cardiovascular disease. This was based upon the results of the LoDoCo2 Trial which showed a 31% (mean) further decrease in major CVD events (heart attack, stroke, coronary surgery or death) compared to placebo in patients with ASCVD who were already on lipid lowering regimens. See trial results: https://www.nejm.org/doi/pdf/10.1056/NEJMoa2021372?articleTools=true Colchicine also has some anti-cancer properties, perhaps beyond the anti inflammatory effects. Patients with gout who take colchicine have a lower incidence of all cancers than gout patients who do not take it. In vitro cell studies have show it can cause G2/M cell cycle arrest and apoptosis and microtubule disruptions among other effects. But it has not been developed as a anti-cancer therapy due to toxicity at the higher doses used.
What anti-inflammatory medicines and supplements might be valuable adjuncts to increasing life/healthspan?
This is a follow-on question to one just posted on low dose colchicine for ASCVD protection. Note that I am an advanced prostate cancer patient and retired physician age 73. Paul Van Camp MD Inflammation is one of the two principle drivers of “The Hallmarks of Cancer” which are the common drivers of progression of cancer from initiation to invasion and spread, to developing resistance to treatments and ultimately to end stage metastasis. (The other main driver being genomic instability: the accumulation of mutations). So the reduction of unnecessary baseline inflammation as well as DNA protection and repair are of paramount importance. https://aacrjournals.org/cancerdiscovery/article/12/1/31/675608/Hallmarks-of-Cancer-New-DimensionsHallmarks-of Inflammation is also one of the main drivers of the diseases of aging (‘Hallmarks of Aging'), of Type 2 diabetes and metabolic syndrome, and of cardiovascular disease. I personally take several agents to decrease my baseline inflammation as measured by my high sensitivity hsCRP tests.This is in attempt to decrease inflammation as a driver of cancer progression, for metabolic health, for risks of the diseases of aging, and cardiovascular disease. Basically all of my major health risks in life outside of infectious diseases! My regimen includes the medicines: Celecoxib, Atorvastin, Metformin, Sirolimus and low dose aspirin. ( I do not take doxycycline because of adverse effects on gut microbiome). My supplements that have anti-inflammatory actions include: Quercetin, Fisetin, Resveratrol, Co Q10, Alpha-lipoic acid, Curcumin, ECGC, Sulforaphane, Omega3 FAs, Melatonin and Pro-biotics. Perhaps I will consider adding low dose colchicine. I would just get the generic 0.6mg and cut them in half to take a very conservative dose of 0.3mg/day. Or perhaps the 0.6mg 3 times per week. We do not want to block ALL inflammation as it is necessary to fight infections and for healing wounds and injuries. Additional study of colchicine and inflammatory pathways in obese with metabolic syndrome: https://www.nature.com/articles/s41366-020-0598-3
Coenzyme Q10
Dear Peter, dear Peter´s team, firstly, thank you for your work and knowledge you are willing to post to the public. I would like to know more about your thoughts related to CoQ10 / especially its function, age relation, role in blood pressure modulation and preventing muscle soreness under statin use or after rigorous exercise. Is there any evidence based data? Is the amount needed for a proper function achievable through specific nutrition or is any supplementation at different ages meaningful? Thank you for your answer.
Metformin raising my glucose readings on CGM
I just started taking Metformin 2 weeks ago. Before, my CGM showed hypoglycemia, particularly during sleeping hours (below 70mg/dl). My average prior was in the 90's and now I am above 110mg/dl) with no low events. My focus is cell function to prevent a second cancer diagnosis. Is Metformin doing what it is supposed to do or am I better off going back to pre-Metformin since the low glucose readings were regular daily?