Lowering LDL below 130 increases All-Cause-Mortality in Korean Study
Hi Peter, I really enjoy what you are doing - especially the Podcast with Andrew Huberman was awesome. Before I considered myself as rather competent in reading a study but I indeed learned a lot from you. I also wanted to post a question to you which is lingering in my head for some time. There has been a study which I am sure you are well aware of (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832139/). In that study ACM increases as LDL is lowered below a certain sweet spot which is around 130 mg/dl. Could you please dive deep into the study and explain your opinion about the findings made and also possible limitations of the study. Thanks in Advance!
Research on harm from variability in glucose levels
Page 325 in Outlive cites Echouffo-Tcheugui et al. (2019) as evidence that variability in glucose levels is harmful. However, that study assessed the health effects of three observations of fasting glucose levels measured 24 months apart. Clearly, this study has nothing to say about the impact of intra-day variations in glucose levels, which is what most people care about. What does the research say about the impact of intra-day variation? In particular, are there studies that have assessed the health effects of intra-day swings of various sizes for people who are not diabetic, and if so, what do these studies say?
Low Dose Naltrexone
Would love an entire episode on LDN. It Has helped so many and the good Drs NPs are using. Sometimes this is even a zero cost medication. It is so underrated and feel is the the best in class re-classification of a drug today. How and why this is used for so many autoimmune diseases and how it work.
What Subpopulations Absolutely Need Zone 2 Cardio and Which Less So?
I'm in a current arc of my life where lengthy exercise sessions are both difficult to schedule regularly, and cause me mental angst for the time-cost I spend doing on them. I like my exercise sessions on the brief and intense end of the spectrum. Without getting into the specifics of my current makeup, what kinds of health markers, constitutions, health goals, or symptomatic complaints would you look at, and say that that Zone 2 exercise is absolutely non-negotiable for maximizing health span, and which are in the basket where you might say that Zone 2 training, though perhaps beneficial, is probably less important?