Urolithin A and it's benefits
Hi Peter, I'm hearing a lot about Urolithin A supplementation at the moment and it's potential benefits for longevity. Although you have mentioned the importance of the gut microbiome in past, as well as mitophagy, I don't believe you have spoken about UA directly (perhaps I've missed an episode if so. There are so many podcasts I want to listen to, sometimes you have to pick and choose! Sorry Peter...). I have read some of the recent studies where there appears to be some promise, but as is the case with most of these supplementation studies there tends to be mixed results. Furthermore, it's also a supplement that seems to be on the higher end when looking to purchase it, not everyone would be able to afford this when added to other supplements they already consume. Perhaps you might be able to delve into UA a little further and advise whether you believe it could be worth the investment. Best wishes
Leaky gut
Dear Dr Attia, I am 77, and since 2021 I have been suffering from digestion-related abdomen aches. All the colonoscopies came out clear, and I tried multiple diets (including a low FODMAP diet), but none of them helped. At the moment I cannot eat many foods because they aggravate my symptoms. I took probiotics, charcoal etc. but none of that helped either. I take multiple supplements for my general health. My doctor thinks it's a leaky gut syndrome, but nothing I tried alleviates the symptoms. What should I do to get better? What diet do you recommend?
Alzheimer's disease
Hi, I have read two of Dr Bredesen's books, describing his protocol. He characterizes it as a systemic, multicausal disease with a set of 'flavors' of the disease that might strike an individual. And proposes a battery of tests to establish the particular flavor an afflicted person. He then proposes systemic management approach (supplements, diet, sleep, exercise, etc) tailored for the person. What is your view on the efficacy of his approach? Would it be possible to interview De Bredesen on your program?
Protein
Both the WSJ and the NYT have recently written articles, quoting nutrition experts, bashing increased protein intake as unnecessary and that the American diet provides the adequate amounts of .36 grams per lb. recommended by the FDA. You were cited in that article for your stance on the need for more protein. The WSJ's article titled "Americans Are Obsessed with Protein and it's Driving Nutrition Expert Nuts" pushes the idea that overload of some amino acids found in protein leads to cardiovascular disease (Bettina Mittendorfer U of Missouri). Help, where are they getting this wrong?
Who will speak up for science?
Given how much time and care you spend to parse through high quality research and platform people who are true experts in their field, I wonder how do you feel about the current dismantling of our system. From the imbecile HHS secretary to NIH funding cuts I wonder who will be the people that actually stand up for science.
Paul Jaminet
Hosting guest Paul Jaminet of Perfecthealthdiet.com--still the best diet and lifestyle book I've ever read. But I realize Peter isn't keen on discussing diet which I understand. Still, Paul is really involved now in cancer therapy (https://angiex.com/about) that looks really innovative. He is a former Harvard astrophysicist.
microalgal oil supplementation compared to fish oil supplementation, Better???
I was listening to your Podcast # 340 AMA#69 About supplements. You mentioned that flax seed and walnuts weren't good sources of Omega 3. I have come across some research on microalgal oil having the same or possibly better benefits to fish oil for those who are vegan or vegetarian. I was listening to your P0dcast # 340 AMA#69 About supplements. You mentioned that flax seed and walnuts weren't good sources of Omega 3. I have come across some research on microalgal oil having the same or possibly better benefits to fish oil for those who are vegan or vegetarian. Do you think these are accurate and show good evidence? Fish Oil and Microalga Omega-3 as Dietary Supplements: A Comparative Study on Cardiovascular Risk Factors in High-Fat Fed Rats. Haimeur A, Mimouni V, Ulmann L, et al. Lipids. 2016;51(9):1037-49. doi:10.1007/s11745-016-4177-2. 2. A Meta-Analysis Shows That Docosahexaenoic Acid From Algal Oil Reduces Serum Triglycerides and Increases HDL-cholesterol and LDL-cholesterol in Persons Without Coronary Heart Disease. Bernstein AM, Ding EL, Willett WC, Rimm EB. The Journal of Nutrition. 2012;142(1):99-104. doi:10.3945/jn.111.148973. 3. Omega-3 Fatty Acids for Nutrition and Medicine: Considering Microalgae Oil as a Vegetarian Source of EPA and DHA. Doughman SD, Krupanidhi S, Sanjeevi CB. Current Diabetes Reviews. 2007;3(3):198-203. doi:10.2174/157339907781368968. Thank you so much
Blood Pressure
I cannot seem to get an accurate blood pressure reading because I go into fight or flight mode every time I even look at the cuff (which I have at home). I am a 58 year-old woman, fit, healthy weight. Recently had a stress, echo due to elevated HR. Stress echo was normal. 24 hour Holter device was normal. I am told adrenaline is the cause. I am fearful of going on blood pressure medicine because I don't believe I need it other than the fact that my readings have been higher due to the fact that I go into fight or flight mode from just anticipating the result.
Fermented Monounsaturated Oil
What do you think of this fermented oil from sugar cane cooking oil? Is there anything "weird" about it? Zero Acre Farms. https://shop.zeroacre.com/checkouts/cn/Z2NwLXVzLXdlc3QxOjAxSlJYWUs5VlMxSDVIRFdOMkZDRkZBS0U4/information?auto_redirect=false&edge_redirect=true&locale=en-US&skip_shop_pay=true
Observable delta in aging
Dr Attia has probably been at the forefront of longevity medicine for 15+ years. He is also approaching the age where many start seeing the impact of aging. Has he started seeing a delta between him and his peers who are not longevity enthusiasts? Basically, I am asking, is Outlive actually working?
Clopidogrel
Now that my benign tumor is out that was waisting my potassium, causing me to have high bp, after 1 year and 4 mos. (after my cardiac infarction) do I still need to take Clopidogrel and "baby" aspirin? My BP is normal and I have remained on Amlodipine Besylate.I am 77 and work out 6 days a week. My CT Plaque number is high, over 500 and I have 2 blocked arteries, but I made corollary arteries and my numbers are all v. good. My cholesterol et al are very. good, no inflammation, no diabetic problems. I am 5' 3" and weigh 122 lbs. I take supplements, but not that many and am careful about magnesium as it's water soluble and not great for my kidneys, though I have nothing wrong with my kidneys. I have an alcoholic drink once every 2 weeks or once a month, usually wine. Am sleeping well now that I take 7.5 mg of Mirtazpine, but I've gained weight on that med., though I feel no other side effects. I do breath work, meditate, and sleep with the NuCalm app.
A1C around 5.9 for 10 years
You recently mentioned a 30 yr old patient with an elevated prediabetic type A1C and said you would no longer wait and see but rather treat this more aggressively. I have had this kind of number for at least 10 yrs. I have a relatively high V02 max for a female (50), the coronary arteries of a "48 yr old" (no plaque at all) (I'm 58), unexplained high c-reactive protein and persistent sleep issues. Metformin did nothing for my blood sugar (over 4months). I'd like to know what are the markers of ill effects from this persistent prediabetic state, why I can't seem to get and stay under 100 on a CGM, regardless of my weight whether 135 or 150 and how I should interpret the inflammation.
High Blood Sugar Spikes in Otherwise Healthy Individuals
Hi Peter, First, I cannot thank you enough for the work that you do and the enormous effort you put in to creating meanigful, impactful. scientifically validated content. You have changed my life. Second, a question regarding CGM data and it's interpretation. My wife, who is unbelievably healthy and in amazing shape, started using a CGM for the first time after listening to me yammering about my CGM data (I so appreciate her patience!). She has found her blood sugars routinely spike to 180-190 after meals and then crash. We have verified with figerstick that these are real. Her meals check every healthy box but include fruit, whole wheat bread, some pasta, beans along with protein and salad. After an hour or so, her sugars have normalized. Her most recent HgA1c was 5.3 and has been creeping up from 5.0 over the past 3 years. As well, her mother has severe dementia, as did her grandmother. This is an obvious concern for us both. She has not had genetic testing...probably more out of fear than anything--which I totally understand. We are both physicians and have felt that in the setting of living a very healthy lifestyle already, knowing her alleles would not inform much in the way of behavior change. As CGM data in the normal population is a relatively new area of study, I have not found much information about exaggerated blood glucose swings in healthy individuals. I am curious if you have had any conversations with investigators looking at the apoE4 gene and relating it to post-prandial blood glucose patterns? There is no way on planet earth she would have worn a CGM had it not been for your podcast and book...so we are eternally grateful to you and to have this information now instead of 20 years from now. I know, a long winded question which may be pretty niche. I thought I would offer my observation and inquire if anyone had been looking at this. Thanks again for all that you do
lactate measuring
i have the Edge meter I find my results all over the place. I am 77 and swim zone two right now place qualfying for worlds masters in august. i am hitting 1.0 4.4 1.1 1.7 for 30 minute swims at about the same speeds varies 6 seconds per 100 yards for the pace. does 1. diet effect lactate production ( sugar or no sugar before the swim or the day before . 2. sleep the night before six to nine hrs . 3. delay after the swim to do the test one to four minutes. 4. time of day doing my swims. 09:00 to 16:00 5. does age (77) narrow the window from too slow ( 1.0 to too fast 4.4 lactate level. I am trying to do two 30 minute swims in a row 4 times a week. I am at 1,8 to 2.1 then the second swim is right after the measured lactate. If less, then faster speed. If too high , how long should I wait? basically how to use the lactate meter maximally