Metabolic health Improvement for obese/overweight patients
Do the studies of Inigo San Millan and others on mitochondrial function prove that once people get obese/ develop insulin resistance it is much harder for them to loose body fat compared to those with healthy mitochondrial function? ( trying to understand if at a certain point obesity is about biology over willpower) ; Do the new medications like semaglutide and Tirzepatide have any improvement on fatty acids oxidation during zone 1-2 training and the mitochondrial function overall at least while the patient is taking them? And is there a way for those with mitochondrial dysfunction to improve their RER / RQ, improve oxidation of fatty acids ? ( trying to understand if there is a way to get my mitochondrial function into a healthy state from dysfunctional).
Astaxanthin: what do you think?
Hi Peter, first thank you for all your incredible work. I was wondering what is your take on Astaxanthin. There are some very positive claims about its effects on a variety of health concerns, and some of those claims seem to be based on what is supposed to be very solid scientific evidence (some say that there are over 3000 papers on the subject, and many studies on human subjects as well). See, for example (but not only) the following from a source (dr Hyman) that seem to be reputable: https://youtu.be/3gZvW-578xw What is your take on Astaxanthin? Strong claims require strong evidence, in my opinion. I couldn't find a comment of yours on the subject .
Fasting and loss of muscle vs loss of fat
If I'm an overweight but not obese 65-year-old female why would I not lose fat when fasting? Why would my body break down muscle versus readily available fat if I'm also weight training and I'm getting adequate protein during non-fasting window (i.e., 3-day fast once per month)?