Metformin and lactate targets for zone 2
I've been performing zone 2 workouts and measuring each workout with a lactate meter to continually adapt my intensity to a level that has blood lactate between 1.7 and 1.9mmol. I'm about to start taking Metformin. I understand I should expect a rise in blood lactate from the Metformin. Should I be revising the target lactate level to account for the use of Metformin?
Current Dietary Studies vs The China Project Protocol
In your book you reference the widely acknowledged shortcomings of most dietary studies (self-reported nutrient intake, high variability of each individual's lifetime diet). The Cornell-Oxford China Project fromthe 1980's avoided these shortcoming and was hailed at the time as the "Grand Prix", "seminal". Why doesn't anyone take their findings into account in the current debates about what a healthy diet should be?
Aligning financial incentives for Med 3.0
It seems a large part of Medicine 3.0 not taking off is that there isn't as much money to be made for preventative care. And as you've mentioned, health insurance isn't incentivized to give you rebates because they might not see the savings if you switch providers. There have been talks for a while about a health score that acts like a credit score that stays with you forever. What are other ways that there would be a better alignment of financial incentives for someone or companies to invest in preventative care?
Over-indexing on protein before 65?
I was listening to Modern Wisdom and host asks what people over index on. You mentioned nutrition, and I wondered to myself if you over index still on nutrition, specifically protein intake. I know you're trying to build up a protein "gas tank" because protein declines with age, but is it possible you have more than plenty for your centenarian decathlon? I ask because of the studies showing lower protein intake is better for longevity under 65. You counter that those studies don't include the decades we're worried about. But could we hedge and eat less protein before 65 and then ramp it to prevent sarcopenia?