Joint Health
I love all of your content, and follow much of your advice quite diligently. The greatest limitation I have regarding exercise is joint issues. I am 60 years old with many years of cycling miles and weight training behind me, and joint issues are the greatest limiting factor for me. Yet I find little in the longevity realm that addresses this. I know how much zone 2 that I should do, what my VO2 max should be, what my lipids should look like, how much protein to eat, etc. but I haven't yet discovered a good, science-based joint health protocol. I'd love to see this topic addressed in future podcasts. Love your work. Thanks.
Could you have an episode Primary Biliary Cholangitis?
Question: Liver health and PBC management. Best practice for longevity, is the subject I would like to hear your expertise on. In Norway 90% diagnosed are women around 60 years old. My main points of interest on the subject are: 1) Importance of circadian clock on medicating. I read “Circadian clock and liver function in health and disease. Journal of Hepathology 2019 vol 71 | 200-211”. This because I found medication should be taken in accordance to function? After the first year of treatment, I was told to take full dose in the evening - My body had a negative reaction, in form of body itchiness and restlessness, made it difficult to sleep, causing tiredness. I decided to the split dosage first recommended: I take 1000mg in the morning (6 AM) and 250mg afternoon (2 PM). After reading the article. Is there a better time of the day to take medication? 2) Weight reduction and control. I have gained weight after medication started and find it difficult loosing weight. Even following a Mediterranean style daily diet. When liver has to be taken extra care of. Background: Woman - 61 years old, diagnosed with PBC at 58 (in 2019). If ethnicity is important, I am Mexican, been living in Norway since 1995. I was diagnosed with PBC, by liver function, blood work and after slow increase in values, was tested positive for AMA. Was passed from my GP to the gastro specialist (Norwegian health system works well), medicated for life with Ursofalk, 1250 mg/ day. My annual control with the specialist is based on looking at my liver values and confirming the continuance of medication. No comorbidity, apparat from obesity. No cholesterol, no diabetes, never smoked. It is my intention to live a good life to 105 years - I have started and stopped many times a program for continuos health. I have more questions but I will stop here. I thank you for your passion for health and longevity.
Meal Timing and Longevity study
Have you seen this study? https://www.nature.com/articles/s41467-023-36546-5 It claims that mid afternoon exercise results in lower hazard result for all cause mortality than exercise at other times particularly for older men. It looks like the majority of the deaths were from cancer or CVD. I wondered if the results could be skewed by diet but could not find anything in the data to confirm. I was wondering if post lunch exercise had the positive effect of limiting glucose spikes from carb heavy lunches resulting in lower risk of diabetes or pre-diabetes and thus lowering the risk of CVD death, or if I am just trying to justify the fact that I prefer early morning workouts. Is there any worry that working out fasted in the early hours could have a negative impact on CVD health?