TG, Apo B, and IR
Hello, Is there an association between blood TG and LDLP/Apo B in terms of concentration and/or size? In other words, with high LDLP (discordant to LDL C, 1179 mol/L vs 96 mg/dl) and low TG (36 mg/dl), is it mildly safe to assume a large # of small LDL particles are shuttling TG and thus the low blood TG values coupled to high LDL P?
Optimal blood calcium levels?
What does Peter consider to be optimal blood calcium levels? Could it be detrimental to long-term have blood calcium levels in the upper range, e.g. arterial calcification or building up calcium deposits in vessels/organs? Seems relevant regarding vitamin D and protein supplementation which often leads to higher calcium levels when for example achieved through milk proteins.
Benefit of statin treatment: absolute vs relative improvement, and NNT
There's an impressive improvement in relative risk reduction by taking statins and keeping ApoB low. But the absolute risk reduction is small (ballpark 1%) and the NNT is about 100 (range 50-150 depending on the study.) Keeping 100 people on statins for 5 years in order to prevent one heart attack doesn't seem that impressive. I haven't heard anybody argue why NNT of 100 is a good number or the number is wrong. I'd appreciate your comments on this!
Early 50's rehab
Hi Peter, I'm a 53 year old male, long history of working-out, athletic competition, running, etc. My only real issue is my body mass is a little high. I'm 5'11, 230 lbs. To give you a sense, I'm in the 450 lb hex bar deadlift range, and a cycling VO2 Max around 42/43 - no real squat data because I develop significant knee pain when I straight bar squat. I've also had some lower back issues. 6 weeks ago I began a mobility regimen that focused on long static stretches - 2 to 5 minutes, depending on the movement. All the stretches focused on hamstring, lower back and hip mobility. Typically I do this routine just before going to bed. I provide this background because I really did a number on myself last week. 8:00 AM, and I was in to a warm-up routine that began with abbreviated static stretches and ended with 35 lb Kettlebell Turkish get-ups. On the very first get-up, while transitioning from the kneeled position to the standing position I shifted some weight to my back trailing leg. Instantly my left quadricep tendon snapped. Then, in the instant that I tried to catch myself, my right quad tendon snapped. Yes, bilateral quad tendon tears. I had successful surgery on both knees Friday, and now I begin the long road to recovery. Will be in some form of full or partial mobilization braces for 6 weeks, with progressive range of motion going to 90 degrees by week 6. I then will have every bit of 4 months limited, but progressively increasing activity. Target is near full recovery by 6 months. I have two questions for you. 1. Is there evidence that shows mobility work can weaken tendons? 2. Would enjoy your thoughts on rebuilding muscle mass knowing I'll have limitations for a while, and I'm at an age where building muscle is a bit tougher. FYI, I take Clomiphene Citrate to address moderately low testosterone. (165 ng/dl pre treatment, approximately 400 ng/dl in treatment). Worth noting, I have a great surgeon and treatment team and am committed to following their guidance. If nothing else I thought my case might pose some interesting topics for you to consider.