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Alzheimers

You mentioned to Chris Hemsworth that there are things he can do to mitigate the risk of getting Alzheimers. Can you talk in detail what those things may be?

Fasting vs endurance exercise?

How does fasting compare to endurance exercise? Both seems to stimulate similar biochemical pathways (AMPK, autophagy, ketogenesis etc) unless I’m mistaken, but are there some benefits that are exclusive to either fasting or endurance exercise? Or can endurance exercise just be considered a form of concentrated relative energy deficit by having the metabolic demands acutely go up?

Cell Metabolism

Unless already discussed, I’d love your perspective on this small scale study how late isocaloric eating impacts hunger, energy expenditure & metabolic pathways. https://doi.org/10.1016/j.cmet.2022.09.007

More practical advice

I appreciate the rigor around the science explaining certain diseases, etc, but there isn’t enough content around practical advice. For example, if I have hypertension what would you recommend I do related to diet and also exercise, or if I have atherosclerosis, what should I be doing to prevent “widow maker” besides taking a statin? Can you provide more practical guidance on diet, in particular, for CVD and Hypertension?

Peptides

Have you done a show with an expert in peptides? (Maybe Dr Seeds the author of Peptide Protocol) Couldn’t find through search feature on your website. Some peptides apparently have bad side effects while others seem to be quite beneficial. I’ve heard a lot of benefits to some peptides like BPC157 and CJC-1295. It seems like the benefits are in the same categories you often discuss. Here are som of the benefits copied from a website: Increase in bone density – injuries due to a loss of bone density can increase as we age. Increased cardiovascular strength and muscle mass increase – higher muscle mass decreases body fat by increasing your body’s metabolic rate. Fat burning – an increase in your basal metabolic rate will burn more calories throughout the day. Increase in sex drive – this goes for both men and women. It goes without saying that a lack of proper sexual function has an impact on our mental health. Improved injury recovery – using a hormone replacement program decreases the recovery time for soreness and acute musculoskeletal injuries. Strengthened immune function – CJC 1295 helps you get sick less often. Improvement in cognition and memory – mental clarity and focus are improved. Increased insulin sensitivity – an increase in insulin sensitivity means your overall triglyceride levels are decreased. Lower blood sugar levels burn more body fat. Improved sleep quality – better sleep means better overall mental and physical health.