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Sleep Issues while Fasting

During prolonged fasting (greater than 24H) my sleep becomes shorter and somewhat fitful. These seems to happen to others when I look at online anecdotes. Do you have a solution for sleep issues while fasting?

Accuracy and usefulness of the Dexcom G6 Continuous Glucose Monitor

I recently started using the G6 CGM and was surprised to learn that they consider it functioning correctly if it's +/- 20% vs. a standard glucose monitor. That is a huge variation and I've found that it generally is at least +/- 20% (and not consistently under or over either) which makes me wonder how useful it is in managing (a) variability and (b) not exceeding a maximum like you've described. How do you reconcile the usefulness of the device for those two objectives given how inherently inaccurate it is?

Mendelian Randomization

Could you do a pod cast explaining mendelian randomization and why it is so powerful? What are some of the possible pitfalls? Maybe in the context of analyzing this paper? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724415/#!po=40.4762

Low LDL-C has higher risk for all-cause mortality?

Some studies show that individuals with very low LDL-C have a higher risk for all-cause mortality. How does this reconcile with your guidance that people target low levels of ApoB, especially those with high levels of Lp(a)? https://www.nature.com/articles/s41598-021-01738-w

Gaining weight @ 1500cal intake a day

Hi Piter, I am an ObGyn in Westchester, NY. I have been always interested in nutrition, likely because I always had been fighting with my weight, or it had been fighting with me. Since I was 18yo, living in Kiev, Ukraine, until now 36 years later it is always been a battle. I have been conducting personal experiments of N=1, trying to control things, all my life. I have huge will power, I eat low carb for many years, I exercise average 4x/week - resistance and aerobic, I monitored my intake for month on 3 different Apps, I eat 2/day, I completed 5 day fasts 3 times, I do not drink alcohol. My lab work is normal, although I believe I am Insulin resistant to a degree. Right now if I eat 3rd time a day, or over 1200cal, I gain weight. My DEXA is showing adequate muscle content, normal visceral fat, but also very high SQ fat of 30%, My BMI is 26. Obviously menopause now is a factor, but essentially If I want to relax and stop paying attention for 1 week, I gain around 10lb easy, and than take 6-12 mn to get rid of that. It is very difficult to live like that. I also have plenty of patients who complain of exactly the same. I was wondering if you have any suggestions of were to turn. It would be also interesting to hear not just podcast for women, but specifically menopausal women, since this is a completely different animal all together.