Clarification
I need your help clarifying something. I understand that muscle has non insulin dependent glucose uptake and that muscle acts as a sink to prevent hyperglycemia. While talking with Dr. Layman I think you said 75-80% of glucose goes to skeletal muscle. I also have heard that the brain, liver, and kidneys use up the majority of the bodies energy/ATP. I assume pound for pound the brain is the most energy demanding taking up 20% of the body's energy. Why aren't the brain, liver, and kidneys acting as glucose sinks if they require so much energy?
Knee Replacement early vs. muscle loss by waiting
Incredible information, Peter, thank you for your work. It's very interesting and very often, I find that the target audience is a full doctor, not me. But...I love it. Don't dumb it down! I'm a 54 year old male w/grade 4 chondromalacia in my right knee (left knee replaced 2 years ago after torn meniscus while lifting, due to significant inflammation from significant arthritis). The right patella has a 2cm diameter of grade 4 and my femur is about the same. I’ve been told I walk with a noticeable limp (several times). I have range of motion loss and my knee doesn’t extend fully due to inflammation. I don’t think stem-cell for this type of cartilage loss is likely to work, so I’m stuck with continued muscle loss due to pain and loss of muscle activation due to pain and well…pain. Based on all that I’ve learned from you, I believe you would recommend to replace the knee now, and use what’s left of my 50’s to re-build as much leg muscle and knee strength and stability as possible, vs. waiting 2+ years and then trying to do the same, but with 2 years less muscle. Simple answer - now or later, Peter – replace now…or later. 😊
Is a Calorie a Calorie?
Are all kcals the same when it comes to weight loss/gain? Are they all the same when it comes to health-span? Could you synthesise the literature on studies that control for total calories, and only change macro ratios, and tell us what the results imply for weight management, and for overall health-span. And how practical these findings are in the real-world where people’s food choice and quantity decisions are unconstrained.