Early menopause and faster aging
I would love to hear where the research on timing of menopause and speed of aging stands. This CNN interview seems to suggest that early menopause (before age 50) may lead to rapid aging: https://www.cnn.com/2022/08/20/health/extending-fertility-aging-life-itself-wellness/index.html Would appreciate hearing more about this. TY
Finasteride for lowering prostate cancer risk
Hi Peter, Could you discuss the use of finasteride and its potential use to lower prostate cancer risk. https://pubmed.ncbi.nlm.nih.gov/32282699/ Risks? Starting age? Analysis of current data? It seems to me that current Meta-analysis points to lower over all risk of cancer with finasteride, but increased tumor size. In the episode with Alan Bauman, he seemed to hand waive the tumor size issue as a simple ratio problem. Suppressed DHT will keep prostate smaller than it otherwise would be. As a result, any tumor is larger as a percentage of mass. Thanks
GLP-1 agonists and muscle catabolism
On in your recent podcast with Huberman you said that GLP-1 agonists are catabolic not just for fat but also muscle. I exercise as much as you do and avoid anything that inhibits exercise benefits, so I tried to dig into this idea. Instead of catabolism, I found studies stating GLP-1 agonists actually ameliorate muscle atrophy and sarcopenia. Could you please expand/clarify on the interaction of semaglutide or Rybelsus with muscle? Thank you! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711418/#:~:text=GLP%E2%80%901R%20agonists%20ameliorate%20muscle,of%20atrophy%E2%80%90related%20muscular%20diseases.