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Robust mitochondria more resistant to sepsis?

Lactic acid is a hallmark of sepsis - used for diagnosis and treatment progress. Would cyclists, swimmers, marathoners with robust metabolic function - higher oxidative metabolism and lactic acid utilization (clearance) thresholds be more resistant to sepsis? Reason would suggest they would. Curious if your team or Inigo San-Millan has any insight on this.

Zone 2 and Zone 5 cardio and resistance training balance

Peter and many esteemed exercise physiology guests and professional trainers have spoken in-depth regarding the profound benefits of incorporating Zone 2 base training, periodic Zone 5 anaerobic training, and resistance/strength training into a well designed "centenarian Olympics" training routine. In my 5th decade in being all in on this ! More often than occasionally, it is evident that the performance in the Zone 2 and Zone 5 sessions, as measured by watts/kg (not using lactate measurements), is limited by recent resistance training muscle soreness. Are there any protocols for discussion, training schedule, timing of workouts, Peter's favorite phrase - hacks etc.. that could mitigate this performance impact ?

Rucksack for back

I noticed Peter uses a Rucksack even though he's had back issues in the past. Can we get his views on the benefits and risks of trucking?

Rucksack

Is Rucking bad for your back? Are there benefits for people with previous back pain?

Exercise Before Bed

Hello, I'm very curious about Peter's thoughts on exercise before bed. He may well have addressed this before (apologies!) but I've seen so much conflicting guidance I don't know what to think. Sometimes, night is the only change I get - in those times, should I do it, or is the harm to my sleep not worth the benefit from the exercise? Or is that a leading question, does it even harm your sleep? Thanks!