How should one deal with high HDL-C?
A May 2022 prospective study (n=14 478) in JAMA Cardiology[1] found 1.96× all-cause mortality and 1.71× CV mortality for HDL-C > 80 mg/dL. The study is behind a paywall, so I can't see the details. A friend's HDL-C ranges from 80 to 100 mg/dL. The general question is how she should reduce her risk, which presumably depends on the method of action. In my friend's specific case she also has high LDL-C despite competitive swim training. She seems to be statin-intolerant to boot. Ezetimibe and PCSK9i might be options, but what is the mechanism of HDL-C risk that these might address? What else could she talk to her MD about? Should I pay for a copy of the article to learn more?
Fructose and Layne Norton Energy Balance position
I would like to know how the effects of dosage of fructose in diet and how for Layne Norton with and energy balance model how it reconciled ? I dont think. Remember you asking about the adverse effect of “too much fructose “ in the diet and does stil hold the road for an energy balance model versus CIM? Its a polarizing discussion on all social media, and YouTube, podcast. Can you ask Layne Norton the question and what is your point of view