Your recommendation of 2g of protein per kg of body weight
I read this with interest. As a 70kg male, I would require 140g per day. I am nowhere near this. My questions are: 1) What this evidence to support this recommendation? (Apologies if I have missed it.) 2) Given that, e.g., a salmon fillet has only about 25g of protein, how is it possible to achieve 140g without extreme levels of meat consumption or protein powders? Thanks for the show.
Phenibut
The Drive mentions Phenibut twice in the podcasts; 116, where Dom mentions it and 202, where Peter mentions it as a sleep aid. Both times, it's referenced only in passing. I have a tub of Phenibut that I've rarely used, I've read it's habit forming and has a quick tolerance ramp up. I've taken 250-400mg doses for anti anxiety doses for big work related meetings, but I'm wondering if I could be using it as an occasional sleep aid without any repercussions, right now I'm using THC but we know it's not the best for sleep architecture. Any thoughts on dosing, long term safety, and how habit forming it is?
Osteopenia
Kudos to you and your experts. Your podcast is excellent and has changed my life in retirement. I would love to have you do a deep dive on bones! I am a 68 year old female who is relatively healthy. I recently had a dexascan and was diagnosed with osteopenia. I take omegas, vitamins D and K, Do Zone 2 for an hour 5x/week with resistance 3x/week. I am not sure what I am missing or recommendations to discuss with my Dr. on next steps. Thank you!
Alternative method for performing human intervention studies
I was thinking about how Mendelian randomization has revolutionized the ability to figure out the effects of small genetic changes while maintaining environment and having good cohort matching (ie, using siblings who are in the same environment, eating the same meals, and have very similar genetics except for specific genetic differences being studied). Similarly for interventional (drug, nutrition, exercise, etc) studies, couldn't we just run a study where each person is both in the control group and the study group? Monitor each patient for a year with no intervention, then monitor for a year WITH intervention. Each patient is a perfect cohort to him/herself with exception of being a year older. Depending on the study, one could mix groups so half are in the control the first year and half in the intervention arm, then switch groups the second year.
Insulin Levels
I'm a 43-year-old man who's insulin level dropped from 3.9 muIU/mL to 1.1 muIU/mL in the last 10 months. During that time, I've lost ~25 pounds, gotten stronger, increased by VO2 max, and am eating much healthier and am eating less. What could cause the drop? What should I be concerned about? What adjustments should I make?