Can you clarify the conflicting research on which foods increase arterial epithelial dysfunction and which decrease it?
Can you clarify the conflicting research on which foods increase arterial epithelial dysfunction and which decrease it? For example, I've read that generally, oils increase it, but high polyphenol EVOO decreases it? Avocados, fish, meat, saturated fat: what do they do? There is so much conflicting literature and entrenched camps of thinking: help!
Peter and Productivity
This is perhaps out of the purview of the AMA section, but I find myself always wondering it and do not know where else to ask it. By my counts, Peter: - exercises every day for up to two hours, including strength training and cardio - writes/is writing a book - writes a weekly newsletter - is a full-time doctor, who sees patients - runs two businesses, or at least, a business with two sides to it, and all the marketing, fundraising, admin, etc. that entails --> the podcast-related content, and a self-owned medical practice - appears on other podcasts and media - has a rich portfolio of time-intensive hobbies, such as archery and Formula One - has a family - has a social life beyond family, with friends, goes on trips, is a normal person, etc. I don't understand how one person can handle all this, even with a large, dedicated, and effective team helping him! Any insight into what Peter's day looks like? How many hours is he working? How does he structure / divide it up? How does he deal with lags in energy? I'm sure a conversation on Peter's own productivity could be tied into a broader conversation on energy and health, since I imagine Peter has thought about the best way to align his health regimen and goals with a desire to accomplish everything on his (giant) plate.
Rapamycin & Infertility
Question Rapamycin has demonstrated effects of infertility in both humans and animals, though I believe it was shown to be reversible in animal models. Is there any reason for one to think the fertility issues would persist in humans even beyond discontinuation of the drug? This also likely overlaps with the frequent question of the appropriate age to start rapamycin. One would presumably wish to avoid using it around the time of conception, however, I'm sure people in their early-mid 30's thinking about starting a family would be curious if there would be any downsides to starting and then stopping prior to this time. Background I rarely hear the effects of infertility associated with rapamycin discussed, however, to me it is one of the most compelling indicators of its overlapping mechanisms with caloric restriction in that it seems likely to be diverting energy/resources away from reproductive functions to more maintenance/repair functions (and hopefully retaining reproductive potential for when caloric abundance returns, from an evolutionary perspective, or the drug is discontinued in this case). The question then arises whether the organism is subject to any tradeoffs in temporarily "switching" this reproductive function to a lower or even nonfunctional state.
HIIT and Zone 2 Training
Hi Dr. Pleasure to be reaching out to you. I've heard respected thinkers/practitioners (possibly Dr. Huberman, but for life of me I can't find where he said it) suggest that, whereas HIIT elevates fat burning for a while after an exercise session, and whereas Zone 2 training burns more fat during the process (if less afterward), one might begin with a bout of HIIT and then move on to one's Zone 2 workout, to get the benefit of the increased fat burning (as well as he cardiovascular benefits) from the Zone 2 workout afterward. (Also, it just feels more normal to do a hard effort first and then kindof coast for an hour or so afterward, rather than the opposite). However, on one of your recent shows with Dr. San-Millan, you two seemed to accept as so obvious it went without saying that lactate interferes with lipolysis, and therefore the build-up of lactate that results from HIIT would stymie the benefits of a Zone 2 workout if done (right?) afterward. I would be grateful if you could reconcile these two competing approaches. Many thanks,