Estimate of ApoB
For those of us who have a long history of lipid panels but do not have that same information for ApoB, is there an way to estimate ApoB based on our lipid scores? I found one article that suggested that a good estimation of ApoB can be calculated by =-33.12+0.675(LDL)+11.95(ln(tg)). What do you think of this calculation as an estimate of ApoB?
mitochondrial transplant for anti-aging?
An article in National Geographic[1] suggests that mitochondrial transplants are both possible, and can treat damage, and even possibly aging[2]. Is this worth investigating with an interview? 1. https://www.nationalgeographic.com/science/article/how-a-game-changing-transplant-could-treat-dying-organs 2. https://www.nature.com/articles/s41419-018-0765-9
Altitude Training
Dear Peter, I'm a professional bikerider and I have a masters degree in sport science. To keep up with my knowledge I love your podcasts. Sometimes I have to dive deep back into my knowledge but with the video's it's all quite easy to understand. I particularly loved the episode with dr Inigo San Milan about zone 2 training, but I wondered if it was possible for you to make an episode about endurance athletes and altitude training. What physiological changes are happening? I know our tresholds tend to be 10-15% lower when we are on moderate altitude (2000-2500m) and that this detrimental effect will diminish when you are adapted to altitude. However is there a scientific way to really know when you are adapted to a certain altitude? What type of training is done there? Is it true that it's best to keep the volume quite intact, while lowering intensity? What about taking supplements? It would really be awesome if you could make an episode about this, but of course I also understand if this is too much of a niche to cover in an entire episode Anyway keep up the great work! Best Regards
Home labs; test strips and blood strips?
There are so many finger prick blood test devices, urine and saliva strips, and other devices out there now that claim to give us accurate snapshots of certain biomarkers. Given the importance of so many of them discussed in your podcasts (I'm especially interested in the lactate measurements), is there any reason to test these things at home? Which ones are accurate and which ones are garbage? There are endless test strips on Amazon, a gimmick or possible insights?
Strength confounds Zone 2 measurement?
Thought experiment: two people undergo a Zone 2 test on a bike. They are the same weight and have the exact same degree of metabolic and mitochondrial function at the cellular level. One of those people is a kayaker with strong arms/weak legs, the other a biker with strong legs/weak arms. Wouldn’t their watts/kg at Zone 2 be different, even though their metabolic/mitochondrial health is the same? I realize this is an edge case comparison, but wanted to think about the limits of watts/kg as a metric. And how watts/kg may vary in Zone 2 across different machines. Thank you.