Statins, Biomarker Ratios & Insulin Resistance
You recently discussed the case of a man who presented with IR, with high TRI/HDL-C ratio, etc. If you are taking statins to decrease TRI and LDL while increasing HDL-C, can the numbers be “trusted” or is it essentially an “artificial” set of numbers and ratios that poorly indicate things like the person’s “true” TRI/HDL-C? In other words, should I push my PCP to investigate further if my TRI/HDL-C ratio (on statins) is good but I still suspect IR?
SHBG
You have covered a number of testosterone-related issues on the AMAs, but I don't think I have seen this one discussed. High luteinizing hormone, high follicle stimulating hormone, and high testosterone (so the testes are getting the signals to rev up T production), combined with extremely high sex hormone binding globulin, so that free testosterone is quite low. Are there ways to specifically target and reduce SHBG? Thanks.
How to navigate the health and wellness ecosystem
Hi Peter, I want to preface this by saying that I thing you're doing an INVALUABLE job in this space. And I get it, you're focusing on the three major causes of chronic disease, the foundation of which seems to be metabolic disregulation. There is really no one in this space that makes a better job than you in conveying this message. That said, I ofted feel disoriented, because while in this space there are many people to whom I'd pay no heed, there are voices that FEEL kinda compelling, that DO have some really interesting stories and theories and ideas, like Mark Hyman or Terry Wahls about nutrition, Wim Hof or Patrick McKeown about breathing, and on... but I developed a syndrome that I would call "I don't trust anyone that isn't back by Attia-based evidence". Problem is: you just don't talk about certain topics. I think this comes from the fear of the polarizing effect of everything related to brand-name methods and the nutrition-cults. You know... gut microbiome, leaky gut, antinutrients, influencing your physiology through breathing, ect... Any chance you will do maybe an AMA to adress a way to orient oneself through the maze of the less-than-hard-but-still-interesting-science that goes around?