Damage control for neuro-degenerative diseases
Hi Peter, BIG fan from Italy here, and first up: I'm in love with your work and I want to thank you for being a voice for reason and critical thinking in this crazy world we live in. Second, I won't pretend I don't have personal stakes in this matter, but I want to make it clear that I am NOT asking for specific medical advice, and I also sincerely think your whole community could benefit from an exploration of this topic, being it something truly related to life AND healthspan for many people. On to my question. You speak a lot on the topic of neuro-degenerative diseases, mostly Alzheimer's, and what we can do in our daily life to minimize the risk of cognitive decline and the impact of our genetic predisposition. What if someone already HAS a condition that predisposes them to decline in brain health, be it genetic of otherwise, like multiple sclerosis. Of course this is not a random example, but I guess there's other condition out there that share a similar pattern. Now, fortunately there are great drugs that we can use to slow down and maybe stop altogether the decline, but someone who truly wants do to their best to adopt a "lifestyle" that would help, will be interested in reducing inflamation, promoting neuroplasticity, avoiding traumatic brain injury, and I'm guessing preserving metabolic health to maintain a good brain energy-system. I would love to have your take on this. Also, I'm confused about the role of acute stress here. In a state where the brain is vulnerable, is it good to get the normally "good" eu-stress, like high intensity exercise, sauna, ice baths etc, or would it be a risk not worth taking? And lastly, what about nutrition? Would nutritional ketosis, or even exogenous ketones help, due to their neuro-protective properties? I know this is a layered question, but I feel like this is where you give your best. Thank you, and keep up the GREAT work.
Best longevity HIIT Routine?
Exercise schedule Given the knowledge of the four pillars what would the ideal week or month fitness schedule loom like? —Days/hours per week/month in zone 2 cardio - days/hours per week/month HIIT - days/hours per week/month strength training - days/hours per month general cardio (walking, biking, etc...) I believe all this is in various PODs/AMA/Qualys ie 3 x 60’ per week for zone 2...just looking for an weekly/monthly overview to help guide my routine.
Macros effects when combined
Hi Peter, a huge fan here. I have this question that I don't seem to be able to find answer to anywhere. We have great insight on how macros are treated by our body. What no one touches upon is how that changes when macros are combined. E.g. is there any difference in, consuming on an empty stomach: - a margerita pizza (simple carbs and fat) - a grilled chicken pizza (simple carbs, fat and protein) - a huge bowl of salad followed by the chicken pizza. (sol+non_sol fibre, simple carbs, protein, fat) Are the simple carbs equally "harmful" in all 3 cases? Harmful as in the impact on insulin, rate of absorption by the liver, rate of plasma glucose increase etc. We heard that fructose in fruit is less harmful because its combined with fibre, and some of it doesn't even get absorbed due to it. Why is salad+pizza not the same? thanks!