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Climate Change

A few months ago you asked for suggested guests to discuss climate change, I suggested Alex Epstein, have you made a decision on having a podcast related to climate change?

Inigo San Milan podcast question: strength and mitochondria health

Enjoyed the podcast (again). Forgot how rich that discussion was. I will try and keep this brief... My overarching point here, I guess, is understanding how strength-based training could contribute to mitochondrial health in analogous ways as "junk mileage" ;) zone 2. It's pretty easy in weight training to get your HR to zone 2 numbers throughout a workout. The difference, of course, being that you are usually doing a much more intense effort, thereby recruiting Type II fibers, followed by rest and repeat. Nevertheless, one could easily keep those rest periods such that you are mostly in zone II the entire duration. There are "strength endurance" protocols calling for brief explosive efforts (swings, snatches, etc.) followed by intelligent rest periods and even monitoring of HR to stay in Zone II for upwards to 30-45 min. The goal is to avoid glycolysis and allow enough rest to replenish ATP in the type II fibers before the next intense effort. First round of Questions: 1) Which metabolic pathways under these conditions do you think are creating ATP? 2) Which muscle fibers are needed to generate ATP here? 3) Could one conceivable increase mitochondrial density in type II fibers from such a protocol? Or would type I necessarily have be bear the lion's share of the metabolic work still? Scenario number two. I find an excellent protocol to be strength training efforts with some explosive work followed immediately by walk or ruck. My HR will be nicely elevated from the strength training and by simple walking I can maintain zone II for a decent amount of time before it drops. I am a 31 year former swimmer who would typically need to run or bike to get into zone II without the strength work beforehand. So again, under these conditions in the walking portion: 1) Which metabolic pathways under these conditions do you think are creating ATP? 2) Which muscle fibers are needed to generate ATP here? 3) Is there a difference between scenario 1 and 2 metabolically? More generally, what are differences in steady state zone II vs. explosive energy deficits whereafter the body clearly has to work to replenish that ATP? Is zone II simple a matter of density of work over time no matter the effort or do the types of efforts change the equation here? Sorry.. about as brief as I could make it.. Thank you!

What's the healthiest cookware?

Cookware is made from a variety of materials: ceramic, aluminium, stainless steel, cast iron, etc. Which are best for longevity? My understanding is that some emit a non-negligible amount of toxins.

Are BCAAs bad for longevity?

I am not going to the gym to grow muscle. My sole purpose is longevity. Does it make sense to take BCAAs?

Does Doc Parsley's Sleep Remedy break a fast?

On several occasions Peter Attia mentions taking Doc Parsley's Sleep Remedy to make it easier to fall asleep during a prolonged fast. But I looked at the supplement facts, and I noticed that the Sleep Remedy has 5 calories per 1 packet serving. Doesn't that break the fast and delay autophagy?