Question for Rick Johnson Round 2
For those of us who suffer from high uric acid and gout, but enjoy wine, we understand that this is a trigger. How does wine influence uric acid - is it the same pathway as the fructose pathway? How does wine influence insulin - it should have no impact on the glucose pathway? There are competing views of the benefits of wine, and we note earlier podcasts and AMAs from Peter that debunk the epidemiological analyses. How would drinking wine be good or bad ? Clearly alcohol processing impacts the liver, what about the kidneys, and what are the impacts on blood pressure (acute and chronic)?
Interaction between weight loss, cell loss, and reduced probability of Cancer.
1. When we lose weight, how many cells do we lose? Of course it's impossible to get an exact number, but just want to get a ballpark figure and percentage. 2. If it's pure fat, my understanding is that fat cells get smaller, but are not lost, but how about other non-fat cells? These other non-fat cells may support that extra mass contained in the fat cells, such as bone, veins, skin, blood, immune, etc. 3. If we assign some tiny average probability of a cell going cancerous as p, and let's assume the total probability is basically a independent summation of all the N cells N*p, then wouldn't that imply that fewer cells is lesser probability of Cancer, at least to a first-order approximation? For higher order, guessing "NO" since the contribution of the interaction term between cells and unique characteristics of different types of cells may render the first order approximation too simple.
rapamycin cycling
I have taken rapamycin now under prescription for two years. My DNAge Horvath methylation clock read 6 years below my chronologic age recently, but I neglected to get a pre treatment test. I write about cycling. Is once weekly 2-6mg dosing enough cycling to allow for neurplasticity and other beneficial anabolic effects of MTORC1, or is the two months on and two months off safer? In first principles I migrated from the former to the latter, but would love your take on the literature and insider hearsay. Thanks for all you do.
Rapamycin and ketamine
Katamine is making strides in the management of PTSD and treatment resistant depression. It appears to work in part as an agonist to the MTORC1 receptor which is felt to modulate it’s rapid therapeutic onset via neuroplasticity. As such, should someone in ketamine assisted psychotherapy hold rapamycin. Likely no RCTs here het, but curious about your first principles based answer.