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1 gram of protein per pound of body weight

Peter, As a former athlete who has gained significant weight as I aged yet still have a high muscle mass, I had a question about protein consumption and caloric restriction. You have suggested at least 1 gram of protein per pound of body weight. Is that a good metric even if a person is morbidly obese? In other words, should a person with an ideal weight of 175 pounds that is 250 pounds target 250 grams of protein per day or 175 grams of protein (or somewhere in between)? Thanks.

Newsletter comment - Inflammatory molecule...diabetes and dementia

I greatly appreciated today's newsletter by Taylor Yeater et al. Exceptionally clear and concise

Effect of Artificial sweeteners on Gut bacteria

Does Artificial sweeteners affect gut microbiome ? What is the safest sweetener that will have the least side effect on the gut.

Data showing fasting has longevity benefits that cannot be explained by CR alone

https://pubmed.ncbi.nlm.nih.gov/34663973/

Hashimoto’s

Hi Peter, With Hashimoto’s thyroiditis impacting roughly 17.5% of the adult female population and 6% of the adult male population worldwide, I was hoping you would think about doing a podcast on the subject ( https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.1020709/full?utm_source=chatgpt.com ). Topics like causes, treatments, what role nutrition and exercise play in combating the symptoms, and what science is doing to try and defeat it would all be amazing topics.

What is the best way to support gut microbiome after a colonoscopy.

I have avoided colonoscopy because I think it will wreak havoc on gut microbiome, do you have suggestions on post colonoscopy protocol to optimize gut microbiome?

Post exercise diarrhea in a hot humid climate

I live in Florida and I play tennis for an hour and a half to two hours in the heat. In spite of drinking an electrolyte drink, I will experience diarrhea that day after lunch and dinner. Should I be worried? Is there anything you recommend in order to avoid this?

Absolute body fat mass vs body fat percentage?

Which is more clinically relevant, total body fat mass (in kg or lbs) or body fat percentage? My scale says that I have too high body fat mass, but my body fat percentage is in normal range. Thanks!

Soft Plaque

I have significant “soft plaque” in one major artery in the heart as revealed in a CT Angiogram. How do I manage it? Can it be dissolved? Is there a “functional” Medicine solution? Thank you

APOE4 and GLP-1 agonists

If you had the APOE4/4 genotype would you be taking a GLP-1 agonist purely for the neuroprotective effects? What about if you also needed to lose 20-25 lbs but had no problems with insulin resistance?

Ideal Muscle Mass

Where can I find a good source to learn ideal muscle mass percentage for male and female at different ages?

Cancer Recurrence Prevention Protocol

Would you do anything specific (outside of your regular protocol) for the prevention of cancer recurrence (specifically glioblastoma). Thank you!

Hormone Optimization after Triple Negative Breast Cancer

I've used HRT for over 15 years and felt strong and healthy on it. Now after 2 years clear of Cancer and no exogenous hormones I am losing muscle, energy, quality of life. Are there any studies out there that show more benefits of being on HRT after TNBC than not being on any hormones? Now in my 70's I still challenge myself with weight training but frustrated with little uptick in muscle growth or energy level. As a former athlete, bodybuilder, I'm discouraged that I may have to accept accelerated aging due to lack of restorative hormone levels. Any information I can be directed to will be very appreciated.

Prenuvo

Hi, I'm wondering if the prenuvo scans are worthwhile, or are they just one of the latest trends the Kardashians are spruiking? Thanks for looking at this.

Pre natal bio markers and supplementation

Hi, Can you cover the topic of what blood markers you would test before pregnancy and what supplements/nutrition to consider following blood tests. Thanks, appreciate what you folks are doing

Tinnitus

Where does it come from and would you advise any treatments for it?

Immune systems - why such differences in how often people get sick

Why do some people get sick much more easily and is there anything they can do to strengthen their immune systems? Here I mean normal people, not with severe medical issues. My wife catches every bug going and is laid up with them, I dont catch any of them.

Energy Model of Calorie Intake but Specific CGM Goals?

I've submitted something similar before, but I hear Peter again in this current AMA suggest the energy model means that after protein is covered, carb/fat mix does not really matter. That just seems a bit incomplete or misleading given the importance he places upon glucose management and insulin resistance, learnings from CGMs etc. He has stated goals of minimizing post-prandial spikes and lowering fasted and average glucose levels then it seems from my own CGM experience (and everyone else I've talked to) that the amount of carbs in one's diet definitely matters (along with quality of those carbs, fiber and sugar content, potentially order in which you eat, probably other factors...). Can he please address or clarify this issue at some point? Thanks!

EAAs or BCAAs during fasting?

I know Peter has chjanged his views on BCAAs over the years, recently telling Tim Ferriss he no longer takes them. But if he's recommending small maintenance dose of whey protein during fasting (as mentioned on this week's AMA), why not amp that up with some BCAAs/EAAs as well, which have even fewer calories? In any event, probably worth updating his listeners on his views here. Thanks!

Male Life Expectancy

Despite calls for increased funding of women's health initiatives, on average women live almost 5 years longer than men. While behavioural factors (ex: drinking, suicide) may not favour men, this difference is seen across many mammal species. Are there any insights into why women have longer life expectancies than men? Is there any research underway that may provide some insight? In some ways, couldn't women be the perfect control group to study male life extension?

PerfectAminos

I want to do more fasting but without losing muscle. How well does PerfectAminos supplement work maintain muscle mass during a 3 day water fast?

Uterine Fibroids

Based on the research, what are your thoughts on the impact of Vitamin D on shrinking uterine fibroids?

Hormone replacement for women in their 60's

Can you address the question of whether or not it is beneficial for women in their 60's to take hormone replacement if they have never done so. Is it too late for benefits?

Deodorant and Microwaves

There seems to be a lot of mainstream media outlets talking about how harmful non-natural (aluminum containing) deodorants/anti-perspirants and microwaves are for your health/longevity. What does the research say about how safe, generally speaking, these two classes of products are to use on a daily basis?

My Afib diagnosis

I was diagnosed with afib back in 2017 during a routine annual physical. If it hadn’t been because of the ekg, I would have never known. 8 year later, I remain asymptomatic. I’m an avid cyclist and log about 200 miles per week and do at least one or two HIIT workouts on the trainer during the week. Two of my group rides reach efforts well into Z’s 3-5, and one of them is usually no less than 55 miles. My total cholesterol is 187 and everything else is normal. I just turned 65. What advise can you give me?

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