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Rapamycin and Alzheimer's?

What are your views on current research on rapamycin as preventative for Alzheimer's disease? Any research teams you are tracking that could use help with related efforts?

Favorite Austin BBQ?

We can't be health all the time :)

What is the Niche Use for Superstarch in Ketone Adapted Endurance Athletes

You referenced Superstarch again in your email yesterday (Snap Crackle and Pop). Your field experiment showed that an equivalent dose of Superstarch raised your blood glucose far less than the equivalent amount of carbohydrate in the best complex carbohydrate whole food, which indeed was the premise behind the promotion of Superstarch for endurance athletes. However, as a keto-adapted endurance athlete who now is able to obtain most of my ATP from fat and ketone sources, I am puzzled as to the advantage of adding Superstarch to my daily or post exercise feeding routine (as opposed to continuing as before to limit my daily carbohydrate and protein intake to a threshold that allows continued nutritional ketosis.) Just because I can add Superstarch carbohydrate without generating an insulin spike, what would the benefit of doing so be compared to my current status quo?

Allulose as shadow Fructose

On Podcast 141/ AMA 18 you discussed allulose, as being structurally very similar to fructose, yet not being used by our body for calories the same way. On Podcast 87/Qualy 359 with Rick Johnson, your guest discussed fructose as a substance that plays a very negative role vis-a-vis certain cancers, enabling them in certain ways. Is it known that allulose -- although different from fructose in promoting obesity -- is really not similar to fructose in other ways, in particular in enabling certain cancers? If there is no clinical research on this, specifically, is there some basic science that would inform us? How can a layperson think about such issues?

COVID Vaccine

Dr Attia - Would love to see an AMA on your thoughts on COVID vaccine? I don’t see the value of healthy adults or children putting themselves at risk to get a vaccine when their probability of being sick is so low. As I understand it, the vaccine doesn’t stop or slow the spread. It only helps those that at are at high risk avoid getting very sick. There appears to be a data profile to identify the high risk that we aren’t discussing as a population . Thanks for considering