Can CGM Tech Be Upgraded to Also Read Lactate?
I'm surprised this wasn't asked in the interview with Kevin Sayer of Dexcom. The fact that you can get lactate measurements off of a fingerstick device suggests to my ignorant brain that you ought to be able to read it from interstitial fluid, and there has been some work on this front (e.g. https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2281.1999.00174.x ... though I got a lot of false positives while searching from *muscle* interstitium. If it worked, this would be an enormous improvement in maintaining Zone 2 during training, as well as being much more convenient than trying to do fingersticks during or even immediately after the workout; and, obviously, it would be a huge benefit to diabetics, to more reliably alert users to ketoacidosis. (No, I'm not confusing lactic acidosis with ketoacidosis: https://derangedphysiology.com/main/cicm-primary-exam/required-reading/acid-base-physiology/acid-base-disturbances/Chapter%20824/lactic-acidosis-associated-ketoacidosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610316/ https://content.sciendo.com/view/journals/jtim/7/3/article-p115.xml?language=en Also, diabetics on metformin MAY be at elevated risk of lactic acidosis, as are patients with renal disease (much more common in diabetics).
HIIT
I think you are giving HIIT the short shrift, it should be at the first item of any exercise regime. I don't have any medical training just a guy who has a penchant for self improvement, the evidence shows that HIIT is the must do part of exercise-particularly for the older set. I have attached the how to and why you need to do it links from the Norwegian University of Science and Technology. They have a heart rate calculator you should take a look at. Cheers https://www.ntnu.edu/cerg/advice https://www.ntnu.edu/cerg/hrmax https://www.reddit.com/r/science/comments/7fus15/science_ama_series_my_name_is_ulrik_wisl%C3%B8ff_and_i/
Improving deep sleep
I am a new owner of an Oura ring and am loving the data and feedback I am getting from it. After about a month of data, I am noticing that my deep sleep score is always sub par. I’ve tested whether certain drugs, supplements, and dietary habits are impacting this, and it seems to be a consistent trend regardless of the above factors. I’m wondering if you’ve found any specific drivers in your own experience that increase/decrease the amount of deep sleep you are able to get. Any insight you can provide on how to optimize for specific parts of your sleep (REM, Deep, etc.) would be helpful.
Adoptive Cell Therapy
I’m wondering if/when you’ll be hosting a podcast with an adoptive cell therapy expert? There is so much interesting research being done here and I’d love to get a deep dive on how the various approaches (CAR-T, TCR-T, TILs, NK, etc.) are being prosecuted to treat solid tumors.