Rapamycin, Metformin & COVID 19 Vaccination
I am curious on your thoughts on a person taking a combination of Rapamycin and Metformin for longevity and how that may impact upon the immune system if they were to have a COVID vaccine? Could this possibly increase their COVID symptoms (lowered immune system) and should someone look at boosting their immune system prior to COVID vaccination?
HRV guided zone 2 training (≤LT1-Lactate Threshold 1)
Hi Peter, Hope all is well! Quick question regarding zone 2 training. I recently came across an alternative to using blood lactate sampling using HRV to gauge Z2/LT1 training. This can be reasonably easily be done yourself using a HR strap (e.g. Polar H10), and a mobile phone. Any experience using this method? Seems a good idea to save on the lactate strips, and use this disposable income on more purchases of Topo Chico (in Europe, so haven’t been able to try it myself ;D). As well if you want to expand this makes for a good excuse to break out the math—fractals—on the podcast! Definitions: HRV - Heart Rate Variability: measurement of the beat-to-beat variation between heartbeats. Provides information about autonomic nervous system functioning. LT1 - Lactate threshold 1: point whereafter lactate production and breakdown is no longer in equilibrium. After this point linear increase in blood lactate can be observed with increasing wattage, representing shift in energy metabolism (anaerobic). Phone application: HRV Logger - Marco Altini https://apps.apple.com/nl/app/heart-rate-variability-logger/id683984776 References: 1. Altini, M. (2021, March 1). HRV-based aerobic threshold estimation for endurance athletes: A practical guide. Retrieved March 04, 2021, from https://medium.com/@altini_marco/hrv-based-aerobic-threshold-estimation-for-endurance-athletes-a-practical-guide-8c1d744beae8 2. Goldberger, A., Amaral, L., Hausdorff, J., Ivanov, Pc., Peng, C., & Stanley, H. (2002). Fractal dynamics in physiology: alterations with disease and aging. Proc Natl Acad Sci U S A, 99 Suppl 1, 2466–72. https://doi.org/10.1073/pnas.012579499 4. Gronwald, T., Rogers, B., & Hoos, O. (2020). Fractal Correlation Properties of Heart Rate Variability: A New Biomarker for Intensity Distribution in Endurance Exercise and Training Prescription? Front Physiol, 11, 550572. https://doi.org/10.3389/fphys.2020.550572 3. Kubios. (n.d.). About Heart Rate Variability. Retrieved March 04, 2021, from https://www.kubios.com/about-hrv/
New study linking better outcomes for APOE4 carriers with Choline Supplementation
Have you read the new study published "APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia"? https://stm.sciencemag.org/content/13/583/eaaz4564 Do you think there is value in supplementation for carriers of APOE4 in their early life (40s)? Can you comment on form of Choline Supplementation suggested and dose for a healthy male in 40s? Thank you.
Propose (more) N=1 experiments one can do with the CGM
Considering there is no viable source for insulin data what can a motivated and educated but lay patient determine with the CGM. I am talking beyond just "oh these foods do x to me" and "wow I can get away with $badThing if i do it right after 90 minutes of z2." What objective experiments could you come up with to let someone understand were they are on the insulin resistance spectrum? What objective benchmarks would you design for someone to test to see if their diet and exercise changes are really having a long term effect? Could you talk about case studies of what cgm graphs look like for people who have always been healthy, had t2 or pre t2 and got 'better', what does it look like at 20 and 85 years old? With so many of us now able to access to this tool, help us build a fisher price my first CGM play set. Most of us will only ever get to see our own data so if you could expose us to more examples in context it would at least be interesting if not useful.