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Thoughts on this plant-based vs "ketogenic"-based comparison?

Here is the study: https://www.nature.com/articles/s41591-020-01209-1

Heat and Ketosis e.g. hot baths/hot tubs/saunas

On a recent 3-day dirty fast (coffee and a daily 5-cal bouillon), my ketones dropped from 2.7 mmol/L midday to 1.2 in the evening with only a ~30-min hot bath prior; I was back to 2.9 the next morning. Typically bouillon does not measurably impact my ketones so I'm curious about the effects on fasting and ketosis you see with various heat therapies, and do you recommend modifications to heat therapy practices while on a fast?

zone 2

can I use my age adjusted target heart rate as a proxy for zone 2 exercise?

Benefits of taking enzymes and serrapeptase

Does consumption of serrapeptase and/or enzymes during a fast promote autophagy by helping breakdown of old proteins?

Hormonal replacement therapy for females

Hi Peter, very much enjoying your podcasts. Have my first year medical student son also listening in and gaining insight into critical information not presented in his curriculum! Listened to Podcast 42 with Avrum Bluming and Carol Tavris with great interest. Would be very interested to hear how you are using HRT in your practice for you post-menopausal female patients. What is your take on synthetic vs bio-identical estrogen and progesterone? Are you using oral and/or topical estrogen/progesterone? Thank you for considering this for an AMA episode and all the work you and your team do in putting out a great product.