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New statin guidelines

Listening to recent Robert Luting podcasts, he is really questioning the benefits of statins. he says they are ineffective for primary care (pre heart attack) and that they only lower the non-deleterious part of LDL and not the part that causes cardiovascular disease. he says most people do not need them and the recent revised statin guidance did a meta study that showed this to be true, that statins are not needed for primary prevention. I have ben on statins for many years, has this been a waste? do the new guidelines really say statins are ineffective for anyone primary care. I respect Dr Lustig for metabolic issues but not sure about this one. Is it time for you to do an updated statin AMA that addresses these new guidelines and any recent research on the benefits of statins (or lack thereof),

Over coming anaerobic resistance with Leucine & HMB

I recently saw something on Instagram that said weight training did not build muscles due to anaerobic resistance. The way to fix this was to incorporate the use of amino acid's Leucine & HMB. Can you explain this concept and do you agree with this approach?

Timing of HRT in perimenopause with no vasomotor symtomsand regular periods

Peter, I am so grateful for your interest and dedication to providing evidence based info re HRT for menopausal women. I am a 47 year old woman still having regular periods every 27 days. I am not having hot flashes or other vasomotor symptoms but I do have an array of other new onset symptoms over the past 2 years including joint pain, brain fog, stress / alcohol intolerance, sleep issues, frozen shoulder and other irritating non specific issues. I have had my blood markers checked to rule out autoimmune issues (ANA, hsCRP, rheumatoid factor etc) and all have been very normal. I live in Canada (Toronto) and had no issue getting an HRT Rx (mind you I am a Registered Midwife and my colleagues are OBGYN's so that made a difference in terms of easy access.) I have an Rx for MPA and topical estradiol but I am conflicted on whether or not to start it. I have listened to all of your HRT episodes (except the full AMA as Ive just become a member today) and read all the reco'd books (estrogen matters etc) but I am still not clear on when to start HRT if Im still having regular periods and no hot flashes! I would LOVE to hear you speak more about starting HRT in the perimenopausal period to ease other symtptoms. I have heard you say multiple times that there is benefit in starting HRT prior to menopause, but I am still not clear on risk vs benefit / efficacy for non vasomotor symptoms relief (while still having periods). It is crystal clear that for hot flashes/ sweats HRT can be ++efficacious. I would love to hear more about HRT use for women still having periods with symptoms other that are not vasomotor. I would also love to hear more of your thoughts on HRT vs the pill for perimenopause (comparing doses of hormones, side effects etc) esp as most OB's will hand out the pill like candy wth no resistance when doses of hormones are often higher with the pill - this is very confusing! Thank you for having the most informative and well -articulated podcast out there.

Bicuspid

I found out that I have a bicuspid aortic valve approximately three years ago. I am 52 and only have mild aortic root dilation with very minimal regurgitation with the aortic valve. I am an avid exerciser and love to do everything from resistance exercise, CrossFit, and cardio. I see a preventive cardiologist in Denver who recently told me that continuing with my resistance exercise was OK but I needed to focus on higher reps and lower weight. Please comment on recommendations regarding Bicuspid Aortic valves. Thank you so much!

Avocado oil

When you were discussing oils you mentioned the oils you use/recommend such as olive oil and the ones you don’t recommend but you didn’t mention avocado oil. You did mention eating avocados for the healthy fats so I wondered if by extension you would recommend avocado oil? We use it in cooking for times when the smoke point of olive oil would be contraindicated. Thanks!