how is brain cancer different from cancer in other organs?
Why and how are brain tumors so quickly lethal? Is it because of the location and it cannot really accommodate as much "expansion" as other organs, or there are some particular other aspects of biology that is specific to brain cancers? What is the difference between different types of brain tumors? Is metabolism in brain tumors different due to such a unique lipid-rich avascular environment, and if so, in what way? What is the association with other "horsemen" with brain cancer? I.e., there has already been a discussion about hyperinsulinemia accelerating cancer progression, but what about any of the other ones? Why does there seem to be an inverse relationship between Alzheimer's and cancer - is it because apoe4 is associated with higher inflammation and might be protective? What are particular challenges of treating brain cancers compared to other tumors (delivery through blood brain barrier? any particular aspects of the microenvironment?) Why do some cancers particularly metastasize to the brain? Why does it sometimes seem to occur more frequently in children compared to other cancers? (I.e., why do kids, if they do get cancer, seem to get more brain tumors than other types of cancer?) It would be amazing to have a comprehensive podcast on brain cancer! Thank you.