Long term magnesium use effect on gastric motility.
Dr Attia, I've been following your podcast and blog for awhile now and have read outlive at least a few times. I've found the information on magnesium supplementation incredibly valuable. As someone who has personally benefited from magnesium supplementation, especially in regulating anxiety and aiding sleep, I am curious about your thoughts on a recent study I came across. The study, "Effect of chronic administration of magnesium supplement (magnesium glycinate) on male albino Wistar rats’ intestinal (Ileum) motility, body weight changes, food, and water intake" by Umoh et al. (2023), suggests that magnesium may decrease intestinal motility through the beta-adrenergic receptor pathway. While I understand the limitations of this study, particularly its focus on rats, it raised some questions for me, given my recent experiences with magnesium supplementation. I have been taking Slo-Mag daily and a magnesium drink at night to help with sleep for a few years now. I've generally had good results, but this weekend I experienced extreme abdominal pain that lasted unrelentingly for about 10 hours. What was peculiar was that coffee finally seemed to alleviate this pain. I recently switched to a cheaper magnesium supplement (CALM), and since then, I've noticed more GERD symptoms, abdominal bloating, and severe abdominal pains, differing from the laxative effects I've experienced when first starting magnesium in the past. Based on the findings of the aforementioned study and considering my symptoms/alleviation with a known gut smooth muscle stimulant, do you think long-term use of certain magnesium supplements (other than magnesium l-threonate) could lead to gastroparesis or decreased smooth muscle motility? Or would you consider my experience an isolated event? I'm trying to understand if there's a connection between my magnesium intake and these abdominal issues. I appreciate your insights on this matter. Reference: Umoh et al. (2023). "Effect of chronic administration of magnesium supplement (magnesium glycinate) on male albino Wistar rats’ intestinal (Ileum) motility, body weight changes, food and water intake." Heliyon, 9(8).
Fasting
Hi There I am 54 years old, pretty fit (75kg train weights/cardio 5 day a week) no or little alcohol not much sugar (love 1 teaspoon in coffee once a day) Ive been doing the daily fasting (starting from last meal night before, usually finished eating by 8 pm ) and fasting until 11 am or later the next day, 5 days a week Questions... 1. I train in the morning at about 9am at the gym and because Im fasting until 11 or later some days Im afraid I might be missing out on the Protein window. As Im already pretty lean Any thoughts? Or would it be better to do some more intense fasting on the days I dont do gym/training?? Love to hear your thoughts Thanks
Dr. Bernstein
Please consider an interview with Dr. Richard K Bernstien while he is still alive. His early work in diabetic management was outlined in chapter 12 of the new book Rethinking Diabetes by Gary Taubes and was an interesting episode in the history of medicine. It might be helpful to review the whole book
calorimetry
Hello. Having listened to many of Peter's podcasts, I ran a cross a new product that looks interesting in general, and given his proclivity to measure aspects of his physiological function, he may be interested. I have ordered one for myself, but it hasn't arrived. It is a breath calorimeter manufactured by Calibre. They are reporting a high level of device accuracy as compared to the commercial breather calorimeters. The device is around $500. If it works, it would be a nice option to be able to do vo2 max testing more frequent tly and on ones own preferred gear. I am also in this cohort of the Early program