Notes from Podcast #273 on prostate health
From episode #273, Ted Schaeffer said if the alpha blocker is helping with stream but patient still needs to urinate too frequently, you can use an antimuscarinic (older drug, undesired like 5𝛼-reductase inhibitors) or an M3 agonist. What are some M3 agonist options I can suggest to my doctor? He currently has me on Oxybutynin https://en.wikipedia.org/wiki/Oxybutynin which I wish to avoid given Ted's comments.
How Do You Treat Patients with Chronic Fatigue Syndrome?
Hello, I would greatly appreciate an AMA on how you treat patients with Chronic Fatigue Syndrome. PsychSceneHub has a great literature review article, and Dr. Kanojia (who runs the YouTube channel HealthyGamerGG) has had some fascinating lectures on psychosomatic illnesses, of which CFS can be considered. My brother has been dealing with CFS for over a decade, and we've been wondering how to treat it. The literature review pointed out systemic inflammation and immunological changes as partial culprits for the fatigue. Specifically, an imbalance between T helper cells, low NK cells, and mild activation of TNF, IL-6, and IL-1. I would really, really love to hear a deep dive on what this means: where are the IL's released from, how do they travel in the body, and what effects on organs do they have? Inflammation is rarely defined in online discussions, yet it's used so often I feel it has lost all meaning. The article says that fatigue severity significantly correlates with inflammation. What might be causing this inflammation? What separates 'acute' vs 'systemic' inflammation? Do specific foods increase inflammation? If so, in what way, and how? The review also points towards mitochondrial abnormalities. Does this mean Zone 2 exercise, which improves mitochondrial health, may be useful? What should we do if someone has post exertional malaise, and struggles with exercise? The point on an imbalance between aerobic and anaerobic metabolism may be relevant here too. I'm generally confident that losing weight (therefore decreasing adipokine secretion), eating healthier, improving sleep quality, zone 2 exercise, improving emotional health, may be helpful. But my brother is doubtful that stuff would make a dent in his fatigue. Beyond CFS, I wonder what you recommend for your patients who feel bleh all the time, but don't have the severity of CFS? What is energy? What is going on in the brain and body when someone feels energized? What are the specific energy systems or neurotransmitters? Although Zone 2 improves mitochondrial health, does that actually translate to the subjective feeling of having more energy? Thank you so much for taking the time to read this! As a pre-medical student, the many articles are fascinating to read. Your work has changed many aspects of my life, and I am incredibly grateful for you and your team's work.
What benefits are there to eating a high protein diet beyond muscle synthesis?
Does eating a high protein diet (0.73-1 gram per pound of ideal bodyweight) have benefits beyond muscle synthesis? In the book, you mentioned many other uses for amino acids within the body, such as synthesizing antibodies. Does eating more protein help the immune system for example? Thanks!